Cancer Stem Cells in Pancreatic Ductal Adenocarcinoma

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dc.contributor.authorBubin, Roman
dc.contributor.authorUljanovs, Romans
dc.contributor.authorStrumfa, Ilze
dc.contributor.institutionDepartment of Pathology
dc.date.accessioned2023-05-20T07:35:01Z
dc.date.available2023-05-20T07:35:01Z
dc.date.issued2023-04
dc.descriptionPublisher Copyright: © 2023 by the authors.
dc.description.abstractThe first discovery of cancer stem cells (CSCs) in leukaemia triggered active research on stemness in neoplastic tissues. CSCs represent a subpopulation of malignant cells, defined by unique properties: a dedifferentiated state, self-renewal, pluripotency, an inherent resistance to chemo- and radiotherapy, the presence of certain epigenetic alterations, as well as a higher tumorigenicity in comparison with the general population of cancer cells. A combination of these features highlights CSCs as a high-priority target during cancer treatment. The presence of CSCs has been confirmed in multiple malignancies, including pancreatic ductal adenocarcinoma, an entity that is well known for its dismal prognosis. As the aggressive course of pancreatic carcinoma is partly attributable to treatment resistance, CSCs could contribute to adverse outcomes. The aim of this review is to summarize the current information regarding the markers and molecular features of CSCs in pancreatic ductal adenocarcinoma and the therapeutic options to remove them.en
dc.description.statusPeer reviewed
dc.format.extent23
dc.format.extent2902243
dc.identifier.citationBubin, R, Uljanovs, R & Strumfa, I 2023, 'Cancer Stem Cells in Pancreatic Ductal Adenocarcinoma', International Journal of Molecular Sciences, vol. 24, no. 8, 7030, pp. 1-23. https://doi.org/10.3390/ijms24087030
dc.identifier.doi10.3390/ijms24087030
dc.identifier.issn1661-6596
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/12147
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85156182621&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcancer stem cells
dc.subjectepigenetics
dc.subjectepithelial–mesenchymal transition
dc.subjectpancreatic ductal adenocarcinoma
dc.subjectsignalling pathways
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectCatalysis
dc.subjectMolecular Biology
dc.subjectSpectroscopy
dc.subjectComputer Science Applications
dc.subjectPhysical and Theoretical Chemistry
dc.subjectOrganic Chemistry
dc.subjectInorganic Chemistry
dc.subjectSDG 3 - Good Health and Well-being
dc.titleCancer Stem Cells in Pancreatic Ductal Adenocarcinomaen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

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