Association between Alopecia Areata and Lifestyle Factors
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Date
2022
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Rīgas Stradiņa universitāte
Rīga Stradiņš University
Rīga Stradiņš University
Abstract
Ievads: Alopecia areata jeb perēkļveida matu izkrišana ir autoimūnas izcelsmes alopēcijas forma, kas nerada rētas. Klīniski šī slimība izpaužas kā matu izkrišanas laukumi uz galvas ādas, bārdas un ķermeņa, kas var būt dažāda lieluma un daudzuma. Visā populācijā tās izplatība ir aptuveni 2 %, un tā var skart jebkura vecuma cilvēkus, tomēr biežāk slimo gados jauni cilvēki. Tiek uzskatīts, ka perēkļveida matu izkrišana attīstās vides un iedzimtības mijiedarbības rezultātā. Uzturs, kas ietekmē vitamīnu un minerālvielu daudzumu, alkohola lietošana, smēķēšana, slikts miegs un ķermeņa masas indekss var būt modificējami riska faktori alopecia areata attīstībai.
Mērķis: Apskatīt jaunāko literatūru par saistību starp alopecia areata un dzīvesveida faktoriem un novērtēt to terapeitisko potenciālu alopecia areata pacientiem.
Uzdevumi: Veikt literatūras apskatu par alopecia areata, tās etioloģiju, klīniskajām pazīmēm, pašreizējām ārstēšanas stratēģijām un vairāku dzīvesveida faktoru ietekmi uz šo slimību.
Metodika: Meklēt PubMed, Google Scholar, UpToDate un citās atbilstošās datubāzēs literatūru par alopecia areata un saistību ar diētu, miegu, alkoholu, smēķēšanu, ĶMI (ķermeņa masas indeksu), psiholoģisko stresu un citām ar alopecia areata saistītām slimībām, piemēram, atopisko dermatītu un psoriāzi.
Rezultāti un secinājumi: Nav viennozīmīgas vienprātības par to, vai dzīvesveida faktoru izmaiņām ir terapeitisks potenciāls alopecia areata pacientiem. Vairākos pētījumos konstatēta dažādu mainīgo lielumu korelācija starp slimības gaitu, smaguma pakāpi un terapeitisko potenciālu. Tomēr citu pētījumu secinājumi nesakrīt. Šī pētījuma rezultāti uzsver, ka turpmāki dažādu faktoru pētījumi var veicināt slimības un tās patofizioloģijas izpratni.
Background: Alopecia areata is a non-scarring form of alopecia with an autoimmune origin. Clinically, the condition manifests itself as hair loss patches on the scalp, beard, and body that can vary in size and quantity. It has a peak incidence of approximately 2% in the general population and can affect people of any age, however younger individuals are more likely to be affected. It is believed that alopecia areata develops as a result of interplay between environment and heredity. Diet, which affects the levels of vitamins and minerals, alcohol consumption, smoking, poor sleep, and body mass index may all be modifiable risk factors for the development of alopecia areata. Aim: To review the latest literature about the association between alopecia areata and lifestyle factors and to evaluate its therapeutic potential in alopecia areata patients. Tasks: To review literature about alopecia areata, its etiology, clinical features, current treatment strategies and the effect of several lifestyle factors on the disease. Methodology: To search PubMed, Google Scholar, UpToDate, and other relevant databases for literature on alopecia areata, diet, sleep, alcohol, smoking, BMI (body mass index), psychological stress, and other alopecia areata associated diseases such as atopic dermatitis and psoriasis. Results and conclusions: There is no definite consensus on whether lifestyle factors modification have therapeutic potential in patients with alopecia areata. Several studies found a correlation between the disease course, severity, and therapeutic potential of different variables. However, the conclusions of other studies do not follow. The results of this study underline that further research on the different factors may promote the understanding of the disease and its pathophysiology.
Background: Alopecia areata is a non-scarring form of alopecia with an autoimmune origin. Clinically, the condition manifests itself as hair loss patches on the scalp, beard, and body that can vary in size and quantity. It has a peak incidence of approximately 2% in the general population and can affect people of any age, however younger individuals are more likely to be affected. It is believed that alopecia areata develops as a result of interplay between environment and heredity. Diet, which affects the levels of vitamins and minerals, alcohol consumption, smoking, poor sleep, and body mass index may all be modifiable risk factors for the development of alopecia areata. Aim: To review the latest literature about the association between alopecia areata and lifestyle factors and to evaluate its therapeutic potential in alopecia areata patients. Tasks: To review literature about alopecia areata, its etiology, clinical features, current treatment strategies and the effect of several lifestyle factors on the disease. Methodology: To search PubMed, Google Scholar, UpToDate, and other relevant databases for literature on alopecia areata, diet, sleep, alcohol, smoking, BMI (body mass index), psychological stress, and other alopecia areata associated diseases such as atopic dermatitis and psoriasis. Results and conclusions: There is no definite consensus on whether lifestyle factors modification have therapeutic potential in patients with alopecia areata. Several studies found a correlation between the disease course, severity, and therapeutic potential of different variables. However, the conclusions of other studies do not follow. The results of this study underline that further research on the different factors may promote the understanding of the disease and its pathophysiology.
Description
Medicīna
Medicine
Veselības aprūpe
Health Care
Medicine
Veselības aprūpe
Health Care
Keywords
alopecia areata, dzīvesveida faktoru, autoimūna slimība, matu izkrišana, alopecia areata, lifestyle, autoimmune disease, hair loss