Reimatisko slimību izpausmes mutes dobumā
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Date
2022
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Rīgas Stradiņa universitāte
Rīga Stradiņš University
Rīga Stradiņš University
Abstract
Pacientiem ar reimatiskiem traucējumiem bieži rodas mutes dobuma simptomi, kas var būt par iemeslu medicīniskai konsultācijai, turklāt viens no pirmajiem speciālistiem, pie kura pacients varētu vērsties nereti ir zobārsts. Lai gan daži simptomi, piemēram, kserostomija vai mutes čūlas, ir bieži konstatētas sūdzības, citi ir retāk sastopamu traucējumu patognomoni. Tas attiecas uz mikrostomiju SSc pacientiem vai “zemenēm” līdzīgu gingivītu GIA pacientu gadījumā. Tā kā reimatiskās slimības rodas mijiedarbības rezultātā starp ģenētiskajiem mainīgajiem, izmainītām imūnreakcijām uz vides faktoriem, dzīvesveidu un iepriekš vai pašlaik veiktām procedūrām sakarā ar veselības problēmām, tām var būt kopīgi patogēni procesi. Palielinot klīnicista izpratni par reimatiskos procesos iesaistītiem mehānismiem, iespējams uzlabot smagi noritošu mutes un sistēmisko reimatisko slimību seku diagnostiku un ārstēšanu. Tomēr nepieciešami turpmāki pētījumi, lai atrastu un pamatotu iespējamās korelācijas reimatisku slimibu gadījumos.
Patients with rheumatic disorders frequently experience oral symptoms, which may be the motivation for initial medical consultation, possibly being the dental clinician. While some symptoms, like xerostomia or mouth ulcers, are generic and fairly common, others are pathognomonic of uncommon disorders. This is the case with microstomia in SSc patients or “strawberry-like gingivitis” in GIA patients' case. Since rheumatic diseases are the result of interactions between genetic variables, altered immune responses to environmental factors, lifestyles, and previously or presently received healthcare procedures, they may share common pathogenic processes. The diagnosis and treatment of the severe oral and systemic consequences of rheumatic diseases can be improved through increasing the clinician's understanding of the mechanism's involved as well as future studies being conducted so that more correlations can be solidified.
Patients with rheumatic disorders frequently experience oral symptoms, which may be the motivation for initial medical consultation, possibly being the dental clinician. While some symptoms, like xerostomia or mouth ulcers, are generic and fairly common, others are pathognomonic of uncommon disorders. This is the case with microstomia in SSc patients or “strawberry-like gingivitis” in GIA patients' case. Since rheumatic diseases are the result of interactions between genetic variables, altered immune responses to environmental factors, lifestyles, and previously or presently received healthcare procedures, they may share common pathogenic processes. The diagnosis and treatment of the severe oral and systemic consequences of rheumatic diseases can be improved through increasing the clinician's understanding of the mechanism's involved as well as future studies being conducted so that more correlations can be solidified.
Description
Zobārstniecība
Dentistry
Veselības aprūpe
Health Care
Dentistry
Veselības aprūpe
Health Care
Keywords
mutes izpausmes; reimatiskas slimības; reimatoīdais artrīts; juvenīls idiopātisks artrīts; Krona slimība; sistēmiskā skleroze; imūnmediētas miopātijas; Behčeta slimība; milzu šūnu arterīts; sistēmiskā sarkanā vilkēde; Šegrena sindroms; granulomatoze ar poliangītu, oral manifestations; rheumatic diseases; rheumatoid arthritis; juvenile idiopathic arthritis; Crohn’s disease; systemic sclerosis; immune-mediated myopathies; Behcet’s disease; giant cell arteritis; systemic lupus erythematosus; Sjögren’s syndrome; granulomatosis with polyangiitis