Sars-COV-2 Vaccination DID Not Affect the Clinical Course of IGA Nephropathy in Latvian Adult Cohort

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dc.contributor.authorRācenis, Kārlis
dc.contributor.authorJana Saulīte, Anna
dc.contributor.authorPopova, Anna
dc.contributor.authorSaulīte, Mikus
dc.contributor.authorKroiča, Juta
dc.contributor.authorPetersons, Aivars
dc.contributor.authorCernevskis, Harijs
dc.contributor.authorLejnieks, Aivars
dc.contributor.authorOļeiņika, Kristīne
dc.contributor.authorŠlisere, Baiba
dc.contributor.authorSeilis, Janis
dc.contributor.authorKuzema, Viktorija
dc.contributor.institutionDepartment of Biology and Microbiology
dc.contributor.institutionDepartment of Internal Diseases
dc.contributor.institutionDepartment of Human Physiology and Biochemistry
dc.date.accessioned2022-09-14T12:30:01Z
dc.date.available2022-09-14T12:30:01Z
dc.date.issued2022-05-03
dc.description.abstractBACKGROUND AND AIMS: The current strategy to fight against the COVID-19 pandemic involves active patient vaccination. Patients with renal and autoimmune diseases are in high risk for severe COVID-19 infection [1]. Therefore they should be prioritized for vaccination. Immunoglobulin A nephropathy (IgAN) is one of the most common primary glomerulonephritis triggered by mucous membrane alteration; however, there is a discussion about vaccination-caused IgA flare [2]. The immunological nature of IgAN and misleading information in public sources leaves patients skeptical about whether to get vaccinated [3]. The study aimed to investigate the impact of SARS-CoV-2 vaccination on the clinical course of IgA nephropathy. METHOD: Adult patients treated in Pauls Stradins Clinical University Hospital with morphologically proven IgAN were included in the study. Patients with secondary IgAN were excluded. Evaluation of clinical and laboratory markers was performed on inclusion visit and on the second visit 6 months later. SARS-CoV-2 vaccination type and status were noted on both visits. Estimated GFR was calculated with CKD-EPI creatinine-cystatin equation. IBM SPSS Statistics version 27 and Microsoft Excel 10 were used for data analysis. RESULTS: The study involved 54 patients, 36 were unvaccinated and 18 were fully vaccinated. A significant difference between the two groups was observed by baseline proteinuria. Other differences were not observed. Fourteen patients were vaccinated with mRNA vaccine, 13 with Comirnaty and 1 with Spikevax, and four patients were vaccinated with Vaxzevria vector vaccine. The differences between the two groups are shown in Table 1. During study period, two patients had COVID-19 infection; a patient in the vaccinated group had COVID-19 prior to vaccination. CONCLUSION: SARS-CoV-2 vaccination did not affect the clinical course of IgA nephropathy. Our study results indicate that SARS-CoV-2 vaccination in IgA nephropathy patients was safe regarding renal function and disease activity markers. (Table Presented).en
dc.description.statusPeer reviewed
dc.format.extent215340
dc.identifier.citationRācenis, K, Jana Saulīte, A, Popova, A, Saulīte, M, Kroiča, J, Petersons, A, Cernevskis, H, Lejnieks, A, Oļeiņika, K, Šlisere, B, Seilis, J & Kuzema, V 2022, 'Sars-COV-2 Vaccination DID Not Affect the Clinical Course of IGA Nephropathy in Latvian Adult Cohort', Nephrology Dialysis Transplantation, vol. 37, no. Supplement_3, MO213, pp. i145-i146. https://doi.org/10.1093/ndt/gfac067.012
dc.identifier.doi10.1093/ndt/gfac067.012
dc.identifier.issn0931-0509
dc.identifier.othercrossref: 10.1093/ndt/gfac067.012
dc.identifier.otherMendeley: 874a8b15-698d-339b-bc6a-32d699c44f06
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/9542
dc.identifier.urlhttps://www-webofscience-com.db.rsu.lv/wos/alldb/full-record/WOS:000813350700213
dc.identifier.urlhttps://academic.oup.com/ndt/article/doi/10.1093/ndt/gfac067.012/6578473
dc.language.isoeng
dc.relation.ispartofNephrology Dialysis Transplantation
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject3.3 Health sciences
dc.subject3.2 Clinical medicine
dc.subject3.3. Publications in conference proceedings indexed in Web of Science and/or Scopus database
dc.subjectSDG 3 - Good Health and Well-being
dc.titleSars-COV-2 Vaccination DID Not Affect the Clinical Course of IGA Nephropathy in Latvian Adult Cohorten
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/abstract

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