The Effect of High-Intensity Interval Training on Quality of Life and Incidence of Chemotherapy Side Effects in Women With Breast Cancer

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dc.contributor.authorKļaviņa, Aija
dc.contributor.authorCešeiko, Rūdolfs
dc.contributor.authorČampa, Mārtiņš
dc.contributor.authorJermoļenko, Grēta Frančeska
dc.contributor.authorEglītis, Kristaps
dc.contributor.authorLlorente, Alicia
dc.contributor.authorLinē, Aija
dc.contributor.institutionLatvian Academy of Sport Education (LASE)
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2024-12-05T12:55:01Z
dc.date.available2024-12-05T12:55:01Z
dc.date.issued2024-01-01
dc.descriptionPublisher Copyright: © The Author(s) 2024.
dc.description.abstractUNLABELLED Women with breast cancer (BC) experience multiple symptoms related to neoadjuvant chemotherapy (NAC) treatment that impair their functioning and quality of life (QoL). This study aimed to explore the effect of high-intensity aerobic interval training (HIIT) on quality of life and NAC side effects in women with BC. METHODS 56 patients (48.56 (7.84) years, range 35-64 years) diagnosed locally advanced (stage II-III) ER + BC receiving doxorubicin/cyclophosphamide-based NAC were randomly assigned to the HIIT group and a control group (CG) for 6 months. The HIIT group performed 2 to 3 HIIT sessions per week according to the study protocol (4 × 4 minutes at 85%-95% peak heart rate (HR)). The CG followed the standard of care instructions by the oncologists. To assess the QoL participants completed the EORTC QLQ-C30 with the additional BC module of QLQ BR-23. Weekly self-reports on NAC side effects were collected through online survey. RESULTS Study data were analyzed for 37 participants (nHIIT = 17, nCON = 20) who reported at least 14 (60%) weeks. HIIT was effective to reduce BC symptom scale outcomes (ES = 0.113, P = .048), and alleviate systemic therapy side effects (ES = 0.154, P = .020) and cancer related symptoms (ES = 0.124, P = .038). The most common side effect participants experienced at least 1 to 4 days/week was pain (average 50.9% and 56.8% for HIIT and CG, respectively), followed by sleep disturbances (average 50.9% and 49.9%, respectively). About 31% in both groups experienced sleep disturbances 5 to 7 days/week. The NAC induced physical, social and fatigue side effects had significantly lower incidence in HIIT group, while psychological side effects were significantly more common in training group. CONCLUSIONS HIIT is an effective physical exercise program to maintain higher quality of life and help to reduce some of NAC induced side effects for women with BC.en
dc.description.statusPeer reviewed
dc.format.extent11
dc.format.extent628483
dc.identifier.citationKļaviņa, A, Cešeiko, R, Čampa, M, Jermoļenko, G F, Eglītis, K, Llorente, A & Linē, A 2024, 'The Effect of High-Intensity Interval Training on Quality of Life and Incidence of Chemotherapy Side Effects in Women With Breast Cancer', Integrative Cancer Therapies, vol. 23, pp. 1-11. https://doi.org/10.1177/15347354241297385
dc.identifier.doi10.1177/15347354241297385
dc.identifier.issn1534-7354
dc.identifier.otherMendeley: 4e0f0137-e30e-3758-9c00-45d7cec4621e
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/16952
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85209839824&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofIntegrative Cancer Therapies
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbreast cancer
dc.subjectquality of life
dc.subjecthigh intensity interval training
dc.subjectchemotherapy
dc.subjectside effects
dc.subject3.2 Clinical medicine
dc.subject3.3 Health sciences
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectSDG 3 - Good Health and Well-being
dc.titleThe Effect of High-Intensity Interval Training on Quality of Life and Incidence of Chemotherapy Side Effects in Women With Breast Canceren
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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