Antiplatelet Resistance in Patients with Atherosclerosis

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dc.contributor.authorLocāne, Sintija
dc.contributor.authorPūcīte, Elīna
dc.contributor.authorMiglāne, Evija
dc.contributor.authorMillers, Andrejs
dc.contributor.authorNovasa, Arina
dc.contributor.authorIeviņa, Renija
dc.contributor.authorMuravska, Tatjana
dc.contributor.institutionDepartment of Neurology and Neurosurgery
dc.date.accessioned2021-04-12T12:00:03Z
dc.date.available2021-04-12T12:00:03Z
dc.date.issued2019-08
dc.description.abstractVariable platelet response to aspirin and clopidogrel is a well-known phenomenon in patients with coronary artery disease and ischemic cerebral stroke. The objective of the present study was to evaluate the frequency and possible risk factors of antiplatelet resistance in patients with cerebrovascular and cardiovascular diseases. The VerifyNow system was used to evaluate adenosine-5-diphosphate and platelet P2YI2 receptor function in patients with cerebrovascular and cardiovascular disease, who received dual antiplatelet therapy. Aspirin resistance was defined as aspirin reaction units (ARU) >= 550. Clopidogrel resistance was defined as Platelet Reaction Units (PRU) > 230. In the group of cerebrovascular diseases there were 13.2% (n = 27) patients with aspirin and 24.5% (n = 50) with clopidogrel resistance. However, in the cardiovascular group there were 20% (n = 9) aspirin and 11.1% (n = 5) clopidogrel resistant patients. In the cerebrovascular group, aspirin resistant patients had a lower triglyceride level (p = 0.001, r = 0.26) than aspirin sensitive patients. Clopidogrel resistant patients had a significantly higher level of glycated haemoglobin (HbA1C) (p = 0.016, r = 023), triglycerides (p = 0.033, r = 0.16) and lower level of high-density lipoproteins (p = 0.027, r = 0.16) than clopidogrel sensitive patients. In the cardiovascular group, patients who were resistant to aspirin had a significantly higher high-density lipoprotein level (p = 0.038, r = 0.31). No other factors differed significantly between the aspirin or clopidogrel resistant and sensitive patients in the cardiovascular group. Aspirin resistance was more common in patients with cardiovascular disease, and clopidogrel resistance in patients with cerebrovascular disease, although the difference was not significant. Our findings indicate that diabetes mellitus and an elevated level of lipoproteins could be risk factors for aspirin or clopidogrel resistance in patients with cerebrovascular diseases. Further studies should be conducted using larger patient cohorts with balanced groups of patients to investigate clinical aspects of antiplatelet resistance.en
dc.description.statusPeer reviewed
dc.format.extent693163
dc.identifier.citationLocāne, S, Pūcīte, E, Miglāne, E, Millers, A, Novasa, A, Ieviņa, R & Muravska, T 2019, 'Antiplatelet Resistance in Patients with Atherosclerosis', Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences., vol. 73, no. 4, pp. 373-378. https://doi.org/10.2478/prolas-2019-0058
dc.identifier.doi10.2478/prolas-2019-0058
dc.identifier.issn2255-890X
dc.identifier.othercrossref: 10.2478/prolas-2019-0058
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3758
dc.identifier.urlhttps://www.sciendo.com/article/10.2478/prolas-2019-0058
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectaspirin
dc.subjectclopidogrel
dc.subjectresistance
dc.subjectcoronary artery disease
dc.subjectstroke
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAntiplatelet Resistance in Patients with Atherosclerosisen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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