Serodiagnosis of human bocavirus 1 infection among hospitalised children with lower respiratory tract infection in Latvia

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dc.contributor.authorZiemele, Inga
dc.contributor.authorXu, Man
dc.contributor.authorVilmane, Anda
dc.contributor.authorRasa-Dzelzkaleja, Santa
dc.contributor.authorHedman, Klaus
dc.contributor.authorSöderlund-Venermo, Maria
dc.contributor.authorGardovska, Dace
dc.contributor.authorNora-Krukle, Zaiga
dc.contributor.authorMurovska, Modra
dc.contributor.institutionDepartment of Paediatrics
dc.contributor.institutionInstitute of Microbiology and Virology
dc.date.accessioned2021-04-12T10:30:01Z
dc.date.available2021-04-12T10:30:01Z
dc.date.issued2019-08-01
dc.descriptionFunding Information: We thank Lea Hedman for technical advice in serology. This study was supported in part by the Rîga Stradiòð University research project “Epidemiology, pathogenicity of human bocavirus (HBoV) types and their possible connection to lower respiratory tract diseases and acute gastroenteritis in children”, RSU ZP 17/2013, National Research Programme “Biomedicine” project Nr. 5.6.2, the Sigrid Jusélius Foundation, the Life and Health Medical Grant Association, the Jane and Aatos Erkko Foundation, the Medical Society of Finland (FLS), and The Finnish Society of Sciences and Letters. Publisher Copyright: © 2019 Inga Ziemele et al., published by Sciendo 2019. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.
dc.description.abstractSince its discovery in 2005, human bocavirus 1 (HBoV1) has globally been one of the most common respiratory viruses. It is currently accepted that HBoV1 is a pathogen, causing upper and lower respiratory tract infections (LRTIs) in children. However, due to the prolonged HBoV1 DNA shedding from the upper airways and the subsequent high rate of co-detections with other respiratory viruses, the interpretation of positive polymerase chain reaction results is challenging. The aim of this study was to identify acute HBoV1 infections by the presence of HBoV1-specific IgM and IgG measured by competition enzyme immunoassay, to elucidate the induction of Th1/Th2 cytokines, and to describe the clinical characteristics associated with acute HBoV1 infection in hospitalised children less than five years of age with LRTI. HBoV1 IgM was detected in 19/102 (18.6%) and IgG in 66/102 (64.7%) patients. HBoV1 IgM was most frequently found in patients aged 13 to 24 months. Pneumonia and acute wheezing were the most common clinical diagnoses among HBoV1 IgM positive patients. The seroprevalence of HBoV1-specific IgG increased with age, reaching 85% by the age of five years. INF-γ, IL-4, IL-5, and IL-10 were observed to be higher in patients with acute HBoV1 infection.en
dc.description.statusPeer reviewed
dc.format.extent8
dc.format.extent122732
dc.identifier.citationZiemele, I, Xu, M, Vilmane, A, Rasa-Dzelzkaleja, S, Hedman, K, Söderlund-Venermo, M, Gardovska, D, Nora-Krukle, Z & Murovska, M 2019, 'Serodiagnosis of human bocavirus 1 infection among hospitalised children with lower respiratory tract infection in Latvia', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 73, no. 4, pp. 288-295. https://doi.org/10.2478/prolas-2019-0046
dc.identifier.doi10.2478/prolas-2019-0046
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3746
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85069737658&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectchildren
dc.subjectcytokines
dc.subjecthuman bocavirus
dc.subjectlower respiratory tract infection
dc.subjectserology
dc.subject1.6 Biological sciences
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.subjectSDG 3 - Good Health and Well-being
dc.titleSerodiagnosis of human bocavirus 1 infection among hospitalised children with lower respiratory tract infection in Latviaen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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