Relationship between cardiopulmonary, mitochondrial and autonomic nervous system function improvement after an individualised activity programme upon chronic fatigue syndrome patients

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dc.contributor.authorKujawski, Sławomir
dc.contributor.authorCossington, Jo
dc.contributor.authorSłomko, Joanna
dc.contributor.authorZawadka-Kunikowska, Monika
dc.contributor.authorTafil-Klawe, Małgorzata
dc.contributor.authorKlawe, Jacek J.
dc.contributor.authorBuszko, Katarzyna
dc.contributor.authorJakovljevic, Djordje G.
dc.contributor.authorKozakiewicz, Mariusz
dc.contributor.authorMorten, Karl J.
dc.contributor.authorDawes, Helen
dc.contributor.authorStrong, James W.L.
dc.contributor.authorMurovska, Modra
dc.contributor.authorOosterwijck, Jessica Van
dc.contributor.authorEstevez-Lopez, Fernando
dc.contributor.authorNewton, Julia L.
dc.contributor.authorHodges, Lynette
dc.contributor.authorZalewski, Paweł
dc.contributor.institutionInstitute of Microbiology and Virology
dc.date.accessioned2021-10-29T12:45:01Z
dc.date.available2021-10-29T12:45:01Z
dc.date.issued2021-04-01
dc.descriptionPublisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractBackground: The therapeutic effects of exercise from structured activity programmes have recently been questioned; as a result, this study examines the impact of an Individualised Activity Program (IAP) on the relationship with cardiovascular, mitochondrial and fatigue parameters. Methods: Chronic fatigue syndrome (CFS) patients were assessed using Chalder Fatigue Questionnaire (CFQ), Fatigue Severity Score (FSS) and the Fatigue Impact Scale (FIS). VO2peak, VO2submax and heart rate (HR) were assessed using cardiopulmonary exercise testing. Mfn1 and Mfn2 levels in plasma were assessed. A Task Force Monitor was used to assess ANS functioning in supine rest and in response to the Head-Up Tilt Test (HUTT). Results: Thirty-four patients completed 16 weeks of the IAP. The CFQ, FSS and FIS scores decreased significantly along with a significant increase in Mfn1 and Mfn2 levels (p = 0.002 and p = 0.00005, respectively). The relationships between VO2 peak and Mfn1 increase in response to IAP (p = 0.03) and between VO2 at anaerobic threshold and ANS response to the HUTT (p = 0.03) were noted. Conclusions: It is concluded that IAP reduces fatigue and improves functional performance along with changes in autonomic and mitochondrial function. However, caution must be applied as exercise was not well tolerated by 51% of patients.en
dc.description.statusPeer reviewed
dc.format.extent2130241
dc.identifier.citationKujawski, S, Cossington, J, Słomko, J, Zawadka-Kunikowska, M, Tafil-Klawe, M, Klawe, J J, Buszko, K, Jakovljevic, D G, Kozakiewicz, M, Morten, K J, Dawes, H, Strong, J W L, Murovska, M, Oosterwijck, J V, Estevez-Lopez, F, Newton, J L, Hodges, L & Zalewski, P 2021, 'Relationship between cardiopulmonary, mitochondrial and autonomic nervous system function improvement after an individualised activity programme upon chronic fatigue syndrome patients', Journal of clinical medicine, vol. 10, no. 7, 1542. https://doi.org/10.3390/jcm10071542
dc.identifier.doi10.3390/jcm10071542
dc.identifier.issn2077-0383
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6769
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85114070524&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofJournal of clinical medicine
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAutonomic nervous system
dc.subjectChronic fatigue syndrome
dc.subjectExercise
dc.subjectMitofusin
dc.subjectMyalgic encephalomyelitis
dc.subjectOxygen consumption
dc.subject3.2 Clinical medicine
dc.subject3.3 Health sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.titleRelationship between cardiopulmonary, mitochondrial and autonomic nervous system function improvement after an individualised activity programme upon chronic fatigue syndrome patientsen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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