Evaluation of Histological Findings of Airways of Rats Exposed to Highly Polluted Indoor Air in Offices

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dc.contributor.authorMartinsone, Žanna
dc.contributor.authorPilmane, Mara
dc.contributor.authorMoisejevs, Georgijs
dc.contributor.authorSprudža, Dagmara
dc.contributor.authorBaķe, Marite Arija
dc.contributor.institutionInstitute of Occupational Safety and Environmental Health
dc.contributor.institutionInstitute of Anatomy and Anthropology
dc.contributor.institutionBioķīmijas zinātniskā laboratorija
dc.date.accessioned2021-04-26T12:05:01Z
dc.date.available2021-04-26T12:05:01Z
dc.date.issued2016-10-01
dc.descriptionPublisher Copyright: © 2016 Žanna Martinsone et al., published by De Gruyter Open 2016.
dc.description.abstractHumans are exposed to chemicals and PM (particulate matter), including ultrafine particles (nanoparticles), mainly through inhalation. This creates a risk to their health. Another effect to exposure is expression of cytokines and their role in lung inflammation and morphpathogenesis. We conducted a pilot project based on testing of realistic exposure scenarios by describing morphological changes of the respiratory tract in Wistar rats (male) during a 30-day exposure in office where there was high intensity of printing activities. Tracheal tissue of experimental animals had increasing concentrations of inflammatory interleukin IL-1 and decreasing concentrations of IL-6 and TNF-α. The lungs of the experimental animals tended to show focal infiltration of inflammatory cells, vascular plethora, focal and/or diffuse localisation of lymphatic nodules, and also vascular sclerosis and focal emphysema. The results suggested potential dangerous and adverse effect of poor indoor air quality (particles, including nanoparticles, and chemical compounds) on respiratory tract tissue of rats.en
dc.description.statusPeer reviewed
dc.format.extent4
dc.format.extent1433456
dc.identifier.citationMartinsone, Ž, Pilmane, M, Moisejevs, G, Sprudža, D & Baķe, M A 2016, 'Evaluation of Histological Findings of Airways of Rats Exposed to Highly Polluted Indoor Air in Offices', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 70, no. 5, pp. 341-344. https://doi.org/10.1515/prolas-2016-0052
dc.identifier.doi10.1515/prolas-2016-0052
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3919
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85002168782&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIL1
dc.subjectIL6
dc.subjectindoor air quality
dc.subjectrats' lung tissue
dc.subjectrats' trachea tissue
dc.subjectTNF-α
dc.subject3.1 Basic medicine
dc.subject3.3 Health sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.titleEvaluation of Histological Findings of Airways of Rats Exposed to Highly Polluted Indoor Air in Officesen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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