Expert consensus on dynamics of laboratory tests for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis

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dc.contributor.authorChildhood Arthritis & Rheumatology Research Alliance
dc.contributor.authoron behalf of the Pediatric Rheumatology International Trials Organization
dc.contributor.authorPediatric Rheumatology Collaborative Study Group and the Histiocyte Society
dc.contributor.authorDavidsone, Zane
dc.contributor.authorStanevica, Valda
dc.date.accessioned2021-06-15T11:10:01Z
dc.date.available2021-06-15T11:10:01Z
dc.date.issued2016
dc.descriptionAcknowledgements - Valda Stanevicha, MD (Riga, Latvia);
dc.description.abstractObjective: To identify which laboratory tests that change over time are most valuable for the timely diagnosis of macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (sJIA). Methods: A multistep process, based on a combination of expert consensus and analysis of real patient data, was conducted. A panel of experts was first asked to evaluate 115 profiles of patients with MAS, which included the values of laboratory tests at the pre-MAS visit and at MAS onset, and the change in values between the two time points. The experts were asked to choose the 5 laboratory tests in which change was most important for the diagnosis of MAS and to rank the 5 selected tests in order of importance. The relevance of change in laboratory parameters was further discussed and ranked by the same experts at a consensus conference. Results: Platelet count was the most frequently selected test, followed by ferritin level, aspartate aminotransferase (AST), white cell count, neutrophil count, and fibrinogen and erythrocyte sedimentation rate. Ferritin was most frequently assigned the highest score. At the end of the process, platelet count, ferritin level and AST were the laboratory tests in which the experts found change over time to be most important. Conclusions: We identified the laboratory tests in which change over time is most valuable for the early diagnosis of MAS in sJIA. The dynamics of laboratory values during the course of MAS should be further scrutinised in a prospective study in order to establish the optimal cut-off values for their variation.en
dc.description.statusPeer reviewed
dc.format.extent611790
dc.identifier.citationChildhood Arthritis & Rheumatology Research Alliance, on behalf of the Pediatric Rheumatology International Trials Organization, Pediatric Rheumatology Collaborative Study Group and the Histiocyte Society, Davidsone, Z & Stanevica, V 2016, 'Expert consensus on dynamics of laboratory tests for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis', RMD Open, vol. 2, no. 1, e000161. https://doi.org/10.1136/rmdopen-2015-000161
dc.identifier.doi10.1136/rmdopen-2015-000161
dc.identifier.issn2056-5933
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/5037
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84988448976&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofRMD Open
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectImmunology and Allergy
dc.subjectRheumatology
dc.subjectImmunology
dc.titleExpert consensus on dynamics of laboratory tests for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritisen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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