Hemorrhagic Posterior Reversible Encephalopathy Syndrome in a Pediatric Patient With Acute Lymphoblastic Leukemia : A Case Report

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dc.contributor.authorKalēja, Kristīne
dc.contributor.authorSokolovskis, Artūrs
dc.contributor.authorZiemele, Inga
dc.contributor.institutionDepartment of Paediatrics
dc.date.accessioned2024-06-01T08:40:03Z
dc.date.available2024-06-01T08:40:03Z
dc.date.issued2024-03-29
dc.descriptionCopyright © 2024, Kalēja et al.
dc.description.abstractPosterior reversible encephalopathy syndrome (PRES) is an uncommon yet severe neurological disorder characterized by a combination of clinical and radiological features. Common clinical presentations of PRES include headaches, seizures, altered mental status ranging from lethargy to coma, visual disturbances, and behavior changes. This case report outlines the occurrence of hemorrhagic PRES in an 11-year-old girl with B-cell acute lymphoblastic leukemia (ALL) relapse. Hospitalized for ALL relapse, the patient underwent reinduction chemotherapy. On the ninth day of admission, she had a generalized tonic-clonic seizure with a blood pressure peak of 170/120 mmHg. Magnetic resonance imaging (MRI) and a seizure episode suggested PRES. Initially, after the first tonic-clonic seizure, the neurological examination was normal, but after the second seizure, the meningeal symptoms were negative, and gaze palsy and right-sided homonymous hemianopsia were observed; muscle strength was symmetrically reduced in the upper and lower extremitiesand reflexes were symmetrical and diminished. A bilateral Babinski reflex was observed at the time of examination; the patient had mild motor aphasia, and she opened her eyes only in response to tactile stimulation. A follow-up MRI four days after the second seizure episode showed extensive PRES damage with hemorrhagic changes. Over two weeks, the patient's neurological status and blood pressure gradually improved, with persistent changes in the visual field. Subsequent MRI revealed a significant reduction in PRES lesions, but residual hemorrhage measuring 6x4 cm remained evident.en
dc.description.statusPeer reviewed
dc.format.extent343855
dc.identifier.citationKalēja, K, Sokolovskis, A & Ziemele, I 2024, 'Hemorrhagic Posterior Reversible Encephalopathy Syndrome in a Pediatric Patient With Acute Lymphoblastic Leukemia : A Case Report', Cureus, vol. 16, no. 3, e57158. https://doi.org/10.7759/cureus.57158
dc.identifier.doi10.7759/cureus.57158
dc.identifier.issn2168-8184
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/15512
dc.identifier.urlhttps://www-webofscience-com.db.rsu.lv/wos/alldb/full-record/WOS:001205966300026
dc.language.isoeng
dc.relation.ispartofCureus
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectacute lymphoblastic leukemia
dc.subjectchemotherapy
dc.subjecthypertension
dc.subjectintracerebral hemorrhage
dc.subjectposterior reversible encephalopathy syndrome
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleHemorrhagic Posterior Reversible Encephalopathy Syndrome in a Pediatric Patient With Acute Lymphoblastic Leukemia : A Case Reporten
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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