Clinical Symptoms Influencing Parkinson's Patients' Quality of Life in Latvia : A Single-Center Cohort Study

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dc.contributor.authorMinibajeva, Olga
dc.contributor.authorZeltiņa, Estere
dc.contributor.authorKarelis, Guntis
dc.contributor.authorKurjāne, Nataļja
dc.contributor.authorĶēniņa, Viktorija
dc.contributor.institutionDepartment of Doctoral Studies
dc.contributor.institutionDepartment of Infectology
dc.contributor.institutionDepartment of Biology and Microbiology
dc.date.accessioned2023-06-09T13:50:01Z
dc.date.available2023-06-09T13:50:01Z
dc.date.issued2023-05-12
dc.descriptionFunding Information: Rīga Stradiņš University (RSU) supported covering the article processing fee. Publisher Copyright: © 2023 by the authors.
dc.description.abstractBackground and Objectives: Parkinson's disease (PD) is a chronic, progressive illness with a profound impact on health-related quality of life, and it is crucial to know what factors influence the quality of life throughout the course of the disease. This study aimed to evaluate PD patients' motor and non-motor symptoms to compare symptom severity between PD clinical phenotypes and to assess the impact of disease symptoms on quality of life in a cohort of Latvian patients. Materials and Methods: We evaluated 43 patients with Parkinson's disease. Fourteen patients had tremor dominant (TD) PD, twenty-five patients had postural instability/gait difficulty (PIGD), and four patients had a mixed phenotype. Results: The patients' mean age was 65.21 years, and the disease's mean duration was 7 years. The most common non-motor symptoms were fatigue (95.3%), sleep disturbance (83.7%), daytime sleepiness (83.7%), and pain and other sensations (81.4%). PIGD patients had a higher prevalence of depressed mood, daytime sleepiness, constipation, lightheadedness on standing, cognitive impairment, and severe gastrointestinal and urinary disturbances (as assessed using the SCOPA-AUT domains) compared with TD patients. A high prevalence of fatigue was assessed in both disease subtypes. Health-related quality of life significantly statistically correlated with MDS-UPDRS parts III and IV (r = 0.704), the Hoehn and Yahr scale (r = 0.723), as well as the SCOPA-AUT scale's gastrointestinal (r = 0.639), cardiovascular (r = 0.586), thermoregulatory (r = 0.566) and pupillomotor domains (r = 0.597). Conclusions: The severity of motor symptoms, as well as non-motor symptoms, such as fatigue, apathy, sleep problems and daytime sleepiness, pain, and disturbances in gastrointestinal and cardiovascular function, negatively affect PD patients' health-related quality of life. Thermoregulatory and pupillomotor symptoms also significantly affect PD patients' well-being.en
dc.description.statusPeer reviewed
dc.format.extent528205
dc.identifier.citationMinibajeva, O, Zeltiņa, E, Karelis, G, Kurjāne, N & Ķēniņa, V 2023, 'Clinical Symptoms Influencing Parkinson's Patients' Quality of Life in Latvia : A Single-Center Cohort Study', Medicina (Kaunas, Lithuania), vol. 59, no. 5, 935. https://doi.org/10.3390/medicina59050935
dc.identifier.doi10.3390/medicina59050935
dc.identifier.issn1010-660X
dc.identifier.otherPubMedCentral: PMC10222632
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/12327
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85160299591&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofMedicina (Kaunas, Lithuania)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHumans
dc.subjectParkinson's disease
dc.subjectCohort Studies
dc.subjectLatvia/epidemiology
dc.subjectQuality of Life
dc.subjectDisorders of Excessive Somnolence
dc.subjectFatigue/epidemiology
dc.subjectSeverity of Illness Index
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleClinical Symptoms Influencing Parkinson's Patients' Quality of Life in Latvia : A Single-Center Cohort Studyen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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