Mildronate treatment alters γ-butyrobetaine and l -carnitine concentrations in healthy volunteers

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dc.contributor.authorLiepinsh, Edgars
dc.contributor.authorKonrade, Ilze
dc.contributor.authorSkapare, Elina
dc.contributor.authorPugovics, Osvalds
dc.contributor.authorGrinberga, Solveiga
dc.contributor.authorKuka, Janis
dc.contributor.authorKalvinsh, Ivars
dc.contributor.authorDambrova, Maija
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2021-07-06T06:35:01Z
dc.date.available2021-07-06T06:35:01Z
dc.date.issued2011-09
dc.description.abstractObjectives In this study, we aimed to investigate the effects of long-term administration of the cardioprotective drug mildronate on the concentrations of l-carnitine and γ-butyrobetaine in healthy volunteers. Methods Mildronate was administered perorally, at a dosage of 500 mg, twice daily. Plasma and urine samples were collected weekly. Daily meat consumption within an average, non-vegetarian diet was monitored. l-Carnitine, γ-butyrobetaine and mildronate concentrations were measured using the UPLC/MS/MS method. Key findings After 4 weeks, the average concentrations of l-carnitine in plasma significantly decreased by 18%. The plasma concentrations of γ-butyrobetaine increased about two-fold, and this effect was statistically significant in both the male and female groups. In urine samples, a significant increase in l-carnitine and γ-butyrobetaine levels was observed, which provides evidence for increased excretion of both substances during the mildronate treatment. At the end of the treatment period, the plasma concentration of mildronate was 20 μm on average. There were no significant differences between the effects observed in female and male volunteers. Meat consumption partially reduced the l-carnitine-lowering effects induced by mildronate. Conclusions Long-term administration of mildronate significantly lowers l-carnitine plasma concentrations in non-vegetarian, healthy volunteers.en
dc.description.statusPeer reviewed
dc.format.extent7
dc.format.extent317859
dc.identifier.citationLiepinsh, E, Konrade, I, Skapare, E, Pugovics, O, Grinberga, S, Kuka, J, Kalvinsh, I & Dambrova, M 2011, 'Mildronate treatment alters γ-butyrobetaine and l -carnitine concentrations in healthy volunteers', Journal of Pharmacy and Pharmacology, vol. 63, no. 9, pp. 1195-1201. https://doi.org/10.1111/j.2042-7158.2011.01325.x
dc.identifier.doi10.1111/j.2042-7158.2011.01325.x
dc.identifier.issn0022-3573
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/5831
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=80051702880&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofJournal of Pharmacy and Pharmacology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectγ (gamma)-butyrobetaine
dc.subjectl -carnitine
dc.subjectmildronate
dc.subjectUPLC/MS/MS
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectPharmacology
dc.subjectPharmaceutical Science
dc.titleMildronate treatment alters γ-butyrobetaine and l -carnitine concentrations in healthy volunteersen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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