Immunological mechanisms of autoimmune thyroid diseases : A shift in the traditional TH1/TH2 paradigm

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dc.contributor.authorZaķe, Tatjana
dc.contributor.authorSkuja, Sandra
dc.contributor.authorLejnieks, Aivars
dc.contributor.authorGroma, Valerija
dc.contributor.authorKonrade, Ilze
dc.contributor.institutionInstitute of Anatomy and Anthropology
dc.contributor.institutionDepartment of Internal Diseases
dc.date.accessioned2021-04-12T13:10:03Z
dc.date.available2021-04-12T13:10:03Z
dc.date.issued2019-05-01
dc.descriptionFunding Information: This work was supported by the Latvian Council of Science project No. lzp-2018/2-0059. Publisher Copyright: © 2019 Tatjana Zaķe et al., published by Sciendo 2019.
dc.description.abstractAutoimmune thyroid diseases (AITD) mainly include Hashimoto's thyroiditis (HT) and Graves' disease (GD), which are characterised by the presence of circulating antibodies against various thyroid autoantigens and infiltration of the thyroid gland by autoreactive lymphocytes. Despite the significant advancement in the knowledge of AITD pathogenesis in the last decade, the specific immunological mechanisms responsible for development of the disease are not thoroughly understood. Classically, HT has long been considered as a T helper (Th)1-mediated disease, while a Th2-driven autoimmune response is dominant for GD development. However, this classification has changed due to the description of Th17 lymphocytes, which suggested participation of these cells in AITD, particularly HT pathogenesis. Moreover, a shift in the balance between Th17 and T regulatory (Treg) cells has been observed in thyroid autoimmunity. We have observed overexpression of IL-17, the prominent effector cytokine of Th17, within thyroid tissues from HT and GD patients in our studies. The present review will focus on recent data regarding the role of Treg and Th17 lymphocytes in AITD pathogenesis. In addition, the impact and proposed mechanisms of the predominant environmental factors triggering the autoimmune response to the thyroid will be discussed.en
dc.description.statusPeer reviewed
dc.format.extent11
dc.format.extent854252
dc.identifier.citationZaķe, T, Skuja, S, Lejnieks, A, Groma, V & Konrade, I 2019, 'Immunological mechanisms of autoimmune thyroid diseases : A shift in the traditional TH1/TH2 paradigm', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 73, no. 2, pp. 67-77. https://doi.org/10.2478/prolas-2019-0012
dc.identifier.doi10.2478/prolas-2019-0012
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3771
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85065648308&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectenvironmental factors
dc.subjectGraves disease
dc.subjectHashimoto's thyroiditis
dc.subjectT helper 17 cell
dc.subjectT regulatory cell
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.titleImmunological mechanisms of autoimmune thyroid diseases : A shift in the traditional TH1/TH2 paradigmen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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