Defining Criteria for Disease Activity States in Systemic Juvenile Idiopathic Arthritis Based on the Systemic Juvenile Arthritis Disease Activity Score

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dc.contributor.authorRosina, Silvia
dc.contributor.authorRebollo-Giménez, Ana I
dc.contributor.authorTarantola, Letizia
dc.contributor.authorPistorio, Angela
dc.contributor.authorVyzhga, Yulia
dc.contributor.authorEl Miedany, Yasser
dc.contributor.authorLotfy, Hala M
dc.contributor.authorAbu-Shady, Hend
dc.contributor.authorEissa, Mervat
dc.contributor.authorOsman, Naglaa S
dc.contributor.authorHassan, Waleed
dc.contributor.authorMahgoub, Marwa Y
dc.contributor.authorFouad, Nermeen A
dc.contributor.authorMosa, Doaa M
dc.contributor.authorAdel, Yasmin
dc.contributor.authorMohamed, Sheren E M
dc.contributor.authorRadwan, Ahmed R
dc.contributor.authorAbu-Zaid, Mohamed H
dc.contributor.authorTabra, Samar A A
dc.contributor.authorShalaby, Radwa H
dc.contributor.authorNasef, Samah I
dc.contributor.authorKhubchandani, Raju
dc.contributor.authorKhan, Archana
dc.contributor.authorMaldar, Naziya P
dc.contributor.authorOzen, Seza
dc.contributor.authorBayindir, Yagmur
dc.contributor.authorAlsuweiti, Motasem
dc.contributor.authorAlzyoud, Raed
dc.contributor.authorAlmaaitah, Hiba
dc.contributor.authorVilaiyuk, Soamarat
dc.contributor.authorLerkvaleekul, Butsabong
dc.contributor.authorAlexeeva, Ekaterina
dc.contributor.authorDvoryakovskaya, Tatyana
dc.contributor.authorKriulin, Ivan
dc.contributor.authorBracaglia, Claudia
dc.contributor.authorPardeo, Manuela
dc.contributor.authorDe Benedetti, Fabrizio
dc.contributor.authorLicciardi, Francesco
dc.contributor.authorMontin, Davide
dc.contributor.authorRobasto, Francesca
dc.contributor.authorMinoia, Francesca
dc.contributor.authorFilocamo, Giovanni
dc.contributor.authorRossano, Martina
dc.contributor.authorSimonini, Gabriele
dc.contributor.authorMarrani, Edoardo
dc.contributor.authorAbu-Rumeileh, Sarah
dc.contributor.authorKostik, Mikhail M
dc.contributor.authorBelozerov, Konstantin E
dc.contributor.authorPal, Priyankar
dc.contributor.authorBathia, Jigna N
dc.contributor.authorKatsicas, María M
dc.contributor.authorVillarreal, Giselle
dc.contributor.authorMarino, Achille
dc.contributor.authorCosti, Stefania
dc.contributor.authorSztajnbok, Flavio
dc.contributor.authorSilva, Rodrigo M
dc.contributor.authorMaggio, Maria C
dc.contributor.authorEl-Ghoneimy, Dalia H
dc.contributor.authorEl Owaidy, Rasha
dc.contributor.authorCivino, Adele
dc.contributor.authorDiomeda, Federico
dc.contributor.authorAl-Mayouf, Sulaiman M
dc.contributor.authorAl-Sofyani, Fuad
dc.contributor.authorDāvidsone, Zane
dc.contributor.authorPatrone, Elisa
dc.contributor.authorSaad-Magalhães, Claudia
dc.contributor.authorConsolaro, Alessandro
dc.contributor.authorRavelli, Angelo
dc.date.accessioned2025-01-29T09:20:01Z
dc.date.available2025-01-29T09:20:01Z
dc.date.issued2024-09
dc.description© 2024 The Authors. Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology.
dc.description.abstractOBJECTIVE: Our objective was to develop and validate cutoff values in the systemic Juvenile Arthritis Disease Activity Score 10 (sJADAS10) that distinguish the states of inactive disease (ID), minimal disease activity (MDA), moderate disease activity (MoDA), and high disease activity (HDA) in children with systemic juvenile idiopathic arthritis, based on subjective disease state assessment by the treating pediatric rheumatologist. METHODS: The cutoff definition cohort was composed of 400 patients enrolled at 30 pediatric rheumatology centers in 11 countries. Using the subjective physician rating as an external criterion, six methods were applied to identify the cutoffs: mapping, calculation of percentiles of cumulative score distribution, the Youden index, 90% specificity, maximum agreement, and receiver operating characteristic curve analysis. Sixty percent of the patients were assigned to the definition cohort, and 40% were assigned to the validation cohort. Cutoff validation was conducted by assessing discriminative ability. RESULTS: The sJADAS10 cutoffs that separated ID from MDA, MDA from MoDA, and MoDA from HDA were ≤2.9, ≤10, and >20.6, respectively. The cutoffs discriminated strongly among different levels of pain, between patients with and without morning stiffness, and among patients whose parents judged their disease status as remission or persistent activity or flare or were satisfied or not satisfied with current illness outcome. CONCLUSION: The sJADAS cutoffs revealed good metrologic properties in both definition and validation cohorts and are therefore suitable for use in clinical trials and routine practice.en
dc.description.statusPeer reviewed
dc.format.extent9
dc.format.extent653212
dc.identifier.citationRosina, S, Rebollo-Giménez, A I, Tarantola, L, Pistorio, A, Vyzhga, Y, El Miedany, Y, Lotfy, H M, Abu-Shady, H, Eissa, M, Osman, N S, Hassan, W, Mahgoub, M Y, Fouad, N A, Mosa, D M, Adel, Y, Mohamed, S E M, Radwan, A R, Abu-Zaid, M H, Tabra, S A A, Shalaby, R H, Nasef, S I, Khubchandani, R, Khan, A, Maldar, N P, Ozen, S, Bayindir, Y, Alsuweiti, M, Alzyoud, R, Almaaitah, H, Vilaiyuk, S, Lerkvaleekul, B, Alexeeva, E, Dvoryakovskaya, T, Kriulin, I, Bracaglia, C, Pardeo, M, De Benedetti, F, Licciardi, F, Montin, D, Robasto, F, Minoia, F, Filocamo, G, Rossano, M, Simonini, G, Marrani, E, Abu-Rumeileh, S, Kostik, M M, Belozerov, K E, Pal, P, Bathia, J N, Katsicas, M M, Villarreal, G, Marino, A, Costi, S, Sztajnbok, F, Silva, R M, Maggio, M C, El-Ghoneimy, D H, El Owaidy, R, Civino, A, Diomeda, F, Al-Mayouf, S M, Al-Sofyani, F, Dāvidsone, Z, Patrone, E, Saad-Magalhães, C, Consolaro, A & Ravelli, A 2024, 'Defining Criteria for Disease Activity States in Systemic Juvenile Idiopathic Arthritis Based on the Systemic Juvenile Arthritis Disease Activity Score', Arthritis & Rheumatology, vol. 76, no. 9, pp. 1446-1454. https://doi.org/10.1002/art.42865
dc.identifier.doi10.1002/art.42865
dc.identifier.issn2326-5191
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/17056
dc.language.isoeng
dc.relation.ispartofArthritis & Rheumatology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdolescent
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectArthritis, Juvenile/physiopathology
dc.subjectCohort Studies
dc.subjectROC Curve
dc.subjectSeverity of Illness Index
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleDefining Criteria for Disease Activity States in Systemic Juvenile Idiopathic Arthritis Based on the Systemic Juvenile Arthritis Disease Activity Scoreen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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