Novel laboratory tests in assessment of liver function in cute and chronic liver diseases

Simple item page
dc.contributor.authorViksna, Ludmila
dc.contributor.authorKeišs, Jāzeps
dc.contributor.authorSočņevs, Arturs
dc.contributor.authorRozentale, Baiba
dc.contributor.authorPilmane, Mara
dc.contributor.authorSevastjanova, Natalija
dc.contributor.authorBuiķe, Inita
dc.contributor.authorJeruma, Agita
dc.contributor.authorEglite, Elena
dc.contributor.authorĀbeltiņa, Kristīne
dc.contributor.authorSondore, Valentīna
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2021-04-28T09:20:01Z
dc.date.available2021-04-28T09:20:01Z
dc.date.issued2009
dc.descriptionFunding Information: The work was supported by the National Research Programme in Medicine 2006–2009 project No. 10. „Blood-transmissive viral infections affecting life expectancy: viral persistence in human organism and paradigms of diagnostics and treatment”.
dc.description.abstractLiver biopsy in clinical practice has been widely used for the diagnosis and management of patients with liver diseases, particularly, with chronic liver diseases. However, liver biopsy is an invasive method with potential complications, sampling and interpretation errors. Therefore, noninvasive tests are being developed and introduced to replace liver biopsy. The aim of the present study was to identify the new noninvasive methods to be used for the assessment of liver structure and function, by use of the appropriate serum surrogate markers and to evaluate the clinical diagnostic and prognostic accuracy of these methods, including immunogenetic methods, in cases of acute and chronic liver diseases. The obtained data showed that serum markers of apoptosis (cytokeratin-18 neoepitope and citochrome c) and fibrosis (hyaluronic acid) should be included in viral and toxic liver damage management algorithms. The punctual identification of immunogenetic factors (HLA class II antigens) may prove to be useful in predicting disease evolution, and in guiding the appropriate therapy for patients with poor prognosis.en
dc.description.statusPeer reviewed
dc.format.extent6
dc.format.extent203732
dc.identifier.citationViksna, L, Keišs, J, Sočņevs, A, Rozentale, B, Pilmane, M, Sevastjanova, N, Buiķe, I, Jeruma, A, Eglite, E, Ābeltiņa, K & Sondore, V 2009, 'Novel laboratory tests in assessment of liver function in cute and chronic liver diseases', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 63, no. 4-5, pp. 228-233. https://doi.org/10.2478/v10046-009-0035-4
dc.identifier.doi10.2478/v10046-009-0035-4
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3963
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=73349122298&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectApoptosis fibrosis
dc.subjectHLA class II antigens
dc.subjectLiver diseases
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.titleNovel laboratory tests in assessment of liver function in cute and chronic liver diseasesen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Novel_Laboratory.pdf
Size:
198.96 KB
Format:
Adobe Portable Document Format
Download

Collections

Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure