Anemia as a complication of parvovirus B19 infection : In renal transplant recipients

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dc.contributor.authorČapenko, Svetlana
dc.contributor.authorKozireva, Svetlana
dc.contributor.authorFolkmane, Inese
dc.contributor.authorBernarde, Kristina
dc.contributor.authorRozentals, Rafails
dc.contributor.authorMurovska, Modra
dc.contributor.institutionInstitute of Microbiology and Virology
dc.date.accessioned2021-06-09T07:20:01Z
dc.date.available2021-06-09T07:20:01Z
dc.date.issued2012
dc.description.abstractBackground: The frequency of B19 infection in renal transplant donors and recipients was studied to determine the significance of active viral infection in the development of anemia. Material and Methods. Serum, plasma, and peripheral blood leukocyte samples of 47 renal transplant donors, 38 recipients with anemia (Group 1), and 25 without anemia (Group 2) after renal transplantation were evaluated for the presence of anti-B19 specific antibodies (ELISA) and B19 DNA (nPCR). Results: Active persistent B19 infection after renal transplantation was detected in 12 of the 38 in the Group 1 (10 had reactivation and 2 primary infection), and none of the recipients in the Group 2 had it. Of the 12 recipients in the Group 1, 10 were seropositive and 2 seronegative before renal transplantation; 10 received the transplants from the seropositive and 2 from seronegative donors. rHuEPO therapy-resistant severe anemia was detected only in the recipients with active B19 infection after renal transplantation in the Group 1 (7/12). The logistic regression analysis revealed a significant relationship between active B19 infection and severe anemia (OR, 0.039; 95% CI, 0.006-0.257; P=0.001). Conclusions: Active B19 infection was documented only in the anemic recipients and could be associated with the development of severe anemia after renal transplantation. This allows us to recommend concurrent screening for viral DNA in plasma and detection of anti-B19 IgM class antibodies. To find the association between B19 infection and the development of anemia, further investigations are necessary.en
dc.description.statusPeer reviewed
dc.format.extent6
dc.format.extent205538
dc.identifier.citationČapenko, S, Kozireva, S, Folkmane, I, Bernarde, K, Rozentals, R & Murovska, M 2012, 'Anemia as a complication of parvovirus B19 infection : In renal transplant recipients', Medicina (Lithuania), vol. 48, no. 6, pp. 299-304. https://doi.org/10.3390/medicina48060044
dc.identifier.doi10.3390/medicina48060044
dc.identifier.issn1010-660X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/4810
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84866610039&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofMedicina (Lithuania)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnemia
dc.subjectB19 infection
dc.subjectRenal transplantation
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.titleAnemia as a complication of parvovirus B19 infection : In renal transplant recipientsen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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