Oncogenic Effects of HIV-1 Proteins, Mechanisms Behind

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dc.contributor.authorIsaguliants, Maria
dc.contributor.authorBayurova, Ekaterina
dc.contributor.authorAvdoshina, Darya
dc.contributor.authorKondrashova, Alla
dc.contributor.authorChiodi, Francesca
dc.contributor.authorPalefsky, Joel M.
dc.contributor.institutionResearch Department
dc.date.accessioned2021-04-09T11:10:03Z
dc.date.available2021-04-09T11:10:03Z
dc.date.issued2021-01-02
dc.descriptionFunding Information: Funding: This study was supported the Russian Fund for Basic Research grants 17_54_30002 and 20‐04‐01034 to M.I., Latvian Science Council grants LZP‐2018/2‐0308 and LZP‐2020/2‐0376 to M.I., Funding Information: and NCI R01CA 217715 to J.P.The work of Francesca Chiodi is supported by a grant from the Swe‐ dish Medical Research Council (Francesca Chiodi; Vetenskapsrådet 2019‐01169). Publisher Copyright: © 2021 by the authors.
dc.description.abstractPeople living with human immunodeficiency virus (HIV-1) are at increased risk of developing cancer, such as Kaposi sarcoma (KS), non-Hodgkin lymphoma (NHL), cervical cancer, and other cancers associated with chronic viral infections. Traditionally, this is linked to HIV-1-induced immune suppression with depletion of CD4+ T-helper cells, exhaustion of lymphopoiesis and lymphocyte dysfunction. However, the long-term successful implementation of antiretroviral therapy (ART) with an early start did not preclude the oncological complications, implying that HIV-1 and its antigens are directly involved in carcinogenesis and may exert their effects on the background of restored immune system even when present at extremely low levels. Experimental data indicate that HIV-1 virions and single viral antigens can enter a wide variety of cells, including epithelial. This review is focused on the effects of five viral proteins: envelope protein gp120, accessory protein negative factor Nef, matrix protein p17, transactivator of transcription Tat and reverse transcriptase RT. Gp120, Nef, p17, Tat, and RT cause oxidative stress, can be released from HIV-1-infected cells and are oncogenic. All five are in a position to affect “innocent” bystander cells, specifically, to cause the propagation of (pre)existing malignant and malignant transformation of normal epithelial cells, giving grounds to the direct carcinogenic effects of HIV-1.en
dc.description.statusPeer reviewed
dc.format.extent24
dc.format.extent1278161
dc.identifier.citationIsaguliants, M, Bayurova, E, Avdoshina, D, Kondrashova, A, Chiodi, F & Palefsky, J M 2021, 'Oncogenic Effects of HIV-1 Proteins, Mechanisms Behind', Cancers, vol. 13, no. 2, 305, pp. 1-24. https://doi.org/10.3390/cancers13020305
dc.identifier.doi10.3390/cancers13020305
dc.identifier.issn2072-6694
dc.identifier.otherMendeley: 6aa5681c-9841-3827-8ce6-bb9ff4af863c
dc.identifier.otherunpaywall: 10.3390/cancers13020305
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3724
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85099594195&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofCancers
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecthuman immunodeficiency virus type 1
dc.subjectepithelial cells
dc.subjectcarcinogenicity
dc.subjectoxidative stress
dc.subjectreactive oxygen species
dc.subjectgp120
dc.subjectTat
dc.subjectNef
dc.subjectmatrix protein p17
dc.subjectreverse transcriptase
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectSDG 3 - Good Health and Well-being
dc.titleOncogenic Effects of HIV-1 Proteins, Mechanisms Behinden
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

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