Four-Year Outcomes of Left Main Percutaneous Coronary Intervention with a Bioresorbable Scaffold in the Circumflex Ostium

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dc.contributor.authorErglis, Andrejs
dc.contributor.authorNarbute, Inga
dc.contributor.authorSondore, Dace
dc.contributor.authorJegere, Sanda
dc.contributor.authorKumsars, Indulis
dc.contributor.authorDombrovskis, Andis
dc.contributor.authorGrikis, Karlis
dc.contributor.authorBriede, Ieva
dc.contributor.authorDombrovska, Kristine
dc.contributor.authorTrusinskis, Karlis
dc.contributor.authorGrave, Alona
dc.contributor.authorErglis, Martins
dc.contributor.authorKalejs, Martins
dc.contributor.authorStradins, Peteris
dc.contributor.authorStrazdins, Uldis
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2023-01-26T14:05:01Z
dc.date.available2023-01-26T14:05:01Z
dc.date.issued2022
dc.descriptionPublisher Copyright: © 2022 Andrejs Erglis et al.
dc.description.abstractObjectives. The study aimed to investigate the long-term outcomes of a double stent scaffold strategy in patients with left main (LM) bifurcation lesions involving the ostium of the left circumflex artery (LCX), utilizing a drug-eluting stent (DES) in the LM extending into the left anterior descending artery (LAD) and a bioresorbable vascular scaffold (BVS) in the LCX ostium. Background. The high occurrence of in-stent restenosis of the LCX ostium is the major limitation of percutaneous coronary intervention (PCI) for LM lesions with a two-stent strategy. Methods. This was a single-center, prospective, single-arm study of 46 consecutively enrolled patients with a stable coronary artery disease and significant unprotected LM distal bifurcation disease. Patients underwent imaging-guided PCI using DES in the LM-LAD and BVS in the LCX using a T-stent or mini-crush technique. The primary outcome at four years was the composite of death, myocardial infarction, stroke, and target lesion revascularization (TLR). Results. At four years, the primary outcome was identified in 9 patients (19.6%). All events were TLRs except one myocardial infarction due to BVS thrombosis. Seven of the eight TLRs were a result of side branch BVS restenosis. Univariate predictors of the 4-year outcome were higher LDL cholesterol and BVS size ≤2.5 mm. On multivariate analysis, LCX lesion preparation with a cutting balloon and post-procedure use of intravascular ultrasound for optimization were found to be independent protective factors of MACE. Conclusions. In selected patients with LM distal bifurcation disease, an imaging-guided double stent scaffold strategy with DES in the LM and BVS in the LCX ostium was technically successful in all patients and was reasonably safe and effective for four years.en
dc.description.statusPeer reviewed
dc.format.extent331188
dc.identifier.citationErglis, A, Narbute, I, Sondore, D, Jegere, S, Kumsars, I, Dombrovskis, A, Grikis, K, Briede, I, Dombrovska, K, Trusinskis, K, Grave, A, Erglis, M, Kalejs, M, Stradins, P & Strazdins, U 2022, 'Four-Year Outcomes of Left Main Percutaneous Coronary Intervention with a Bioresorbable Scaffold in the Circumflex Ostium', Journal of Interventional Cardiology, vol. 2022, 7934868. https://doi.org/10.1155/2022/7934868
dc.identifier.doi10.1155/2022/7934868
dc.identifier.issn0896-4327
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/10198
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85142283785&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofJournal of Interventional Cardiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectRadiology Nuclear Medicine and imaging
dc.subjectCardiology and Cardiovascular Medicine
dc.titleFour-Year Outcomes of Left Main Percutaneous Coronary Intervention with a Bioresorbable Scaffold in the Circumflex Ostiumen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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