Incidence and outcomes of patients with functionally univentricular heart born in Latvia, 2007 to 2015

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dc.contributor.authorRutka, Katrina
dc.contributor.authorLubaua, Inguna
dc.contributor.authorLigere, Elina
dc.contributor.authorSmildzere, Amanda
dc.contributor.authorOzolins, Valts
dc.contributor.authorBalmaks, Reinis
dc.contributor.institutionDepartment of Anaesthesiology, Intensive Care and Clinical simulations
dc.contributor.institutionDepartment of Paediatrics
dc.contributor.institutionDepartment of Clinical Skills and Medical Technologies
dc.date.accessioned2021-04-22T11:15:01Z
dc.date.available2021-04-22T11:15:01Z
dc.date.issued2018-07
dc.descriptionFunding Information: This study was approved by the Ethics Committee of the Children’s Clinical University Hospital (Decision No. 5-2016; 12 September 2016); given the retrospective nature and absence of any patient identification, the requirement for individual patient or parent consent was waived. Publisher Copyright: © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractBackground and Objectives: A functionally univentricular heart is the term used to describe congenital heart defects where it is impossible to restore two pumping chambers. These lesions are associated with high mortality, morbidity, and medical resource utilization. The aim of this study was to review incidence and outcomes of patients with a functionally univentricular heart at the only pediatric cardiac surgery center in Latvia. Methods: We performed a retrospective review of medical records of (i) all children with a functionally univentricular heart treated at the Clinic of Pediatric Cardiology and Cardiac Surgery, and (ii) all prenatally diagnosed cases of univentricular heart at Children’s Clinical University Hospital in Latvia. We reviewed data regarding children born from January 1, 2007, to December 31, 2015. The children’s cardiac anatomy and interventions were categorized in accordance with the International Pediatric and Congenital Cardiac Code (v3.3). Results: During the study period, 49 patients with a functionally univentricular heart were admitted to Children’s Clinical University Hospital with a corrected incidence of 0.69 per 1000 live births per year. There were 26 patients that had a hypoplastic left ventricle, and 22 patients that had a hypoplastic right ventricle, while one patient had an indeterminate ventricle. Thirty (61.2%) patients had died by the end of data collection. Twenty-one of the 30 deaths occurred before or immediately after stage I surgical palliation. Cumulative neonatal and 5-year survival of patients with a hypoplastic right ventricle was 81.8% and 63.6%, respectively; for patients with hypoplastic left ventricle—46.2% and 17.3%, respectively. Discussion: This is the first mid-term outcome study of patients with a univentricular heart in Latvia. The high mortality reflects the challenges of a small-volume, developing congenital cardiac surgery center. Data from this study will be used as a baseline for quality improvement.en
dc.description.statusPeer reviewed
dc.format.extent1580441
dc.identifier.citationRutka, K, Lubaua, I, Ligere, E, Smildzere, A, Ozolins, V & Balmaks, R 2018, 'Incidence and outcomes of patients with functionally univentricular heart born in Latvia, 2007 to 2015', Medicina (Lithuania), vol. 54, no. 3, 44. https://doi.org/10.3390/medicina54030044
dc.identifier.doi10.3390/medicina54030044
dc.identifier.issn1010-660X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3898
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85053289526&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofMedicina (Lithuania)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFunctionally univentricular heart
dc.subjectHypoplastic left heart syndrome
dc.subjectOutcomes
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.titleIncidence and outcomes of patients with functionally univentricular heart born in Latvia, 2007 to 2015en
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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