Perineural Administration of Dexmedetomidine in Axillary Brachial Plexus Block Provides Safe and Comfortable Sedation : A Randomized Clinical Trial

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dc.contributor.authorRocans, Rihards P.
dc.contributor.authorOzolina, Agnese
dc.contributor.authorAndruskevics, Mareks
dc.contributor.authorNarchi, Patrick
dc.contributor.authorRamane, Diana
dc.contributor.authorMamaja, Biruta
dc.contributor.institutionDepartment of Anaesthesiology, Intensive Care and Clinical simulations
dc.date.accessioned2022-08-16T21:04:12Z
dc.date.available2022-08-16T21:04:12Z
dc.date.issued2022-05-17
dc.descriptionPublisher Copyright: Copyright © 2022 Rocans, Ozolina, Andruskevics, Narchi, Ramane and Mamaja.
dc.description.abstractDexmedetomidine prolongs the duration of regional block while its systemic sedative effect when administered perineurally is unknown. We aimed to evaluate the systemic sedative effect of perineural dexmedetomidine in patients after axillary brachial plexus block (ABPB). This single-blinded prospective randomized control trial included 80 patients undergoing wrist surgery receiving ABPB. Patients were randomized into two groups – Control group (CG, N = 40) and dexmedetomidine group (DG, N = 40). Both groups received ABPB with 20 ml of 0.5% Bupivacaine and 10 ml of 2% Lidocaine. Additionally, patients in DG received 100 mcg of dexmedetomidine perineurally. Depth of sedation was evaluated using Narcontrend Index (NI) and Ramsay Sedation Scale (RSS) immediately after ABPB and in several time points up to 120 min. Duration of block as well as patient satisfaction with sedation was evaluated using a postoperative survey. Our results showed that NI and RSS statistically differed between groups, presenting a deeper level of sedation during the first 90 min in DG compared to controls, P < 0.001. In the first 10 to 60 min after ABPB the median RSS was 4 (IQR within median) and median NI was 60 (IQR 44–80) in DG group, in contrast to CG patients where median RSS was 2 (IQR within median) and median NI was 97 (IQR 96–98) throughout surgery. The level of sedation became equal in both groups 90 and 120 min after ABPB when the median NI value was 98 (97–99) in DG and 97.5 (97–98) in CG, P = 0.276, and the median RSS was 2 (IQR within median) in both groups, P = 0.128. No significant intergroup differences in hemodynamic or respiratory parameters were found. Patients in DG expressed satisfaction with sedation and 86.5% noted that the sensation was similar to ordinary sleep. In DG mean duration of motor block was 13.5 ± 2.1 h and sensory block was 12.7 ± 2.8 h which was significantly longer compared to CG 6.3 ± 1.5 h, P < 0.001 and 6.4 ± 1.8 h, P < 0.001. We found that beside prolongation of analgesia, perineural administration of dexmedetomidine might provide rather safe and comfortable sedation with no significant effect on hemodynamic or respiratory stability and yields a high level of patient satisfaction.en
dc.description.statusPeer reviewed
dc.format.extent7
dc.format.extent360165
dc.identifier.citationRocans, R P, Ozolina, A, Andruskevics, M, Narchi, P, Ramane, D & Mamaja, B 2022, 'Perineural Administration of Dexmedetomidine in Axillary Brachial Plexus Block Provides Safe and Comfortable Sedation : A Randomized Clinical Trial', Frontiers in Medicine, vol. 9, 834778, pp. 1-7. https://doi.org/10.3389/fmed.2022.834778
dc.identifier.doi10.3389/fmed.2022.834778
dc.identifier.issn2296-858X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/9471
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85131520288&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofFrontiers in Medicine
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectaxillary plexus brachialis block
dc.subjectdexmedetomidine
dc.subjectpatient satisfaction
dc.subjectsedation
dc.subjectwrist surgery
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.titlePerineural Administration of Dexmedetomidine in Axillary Brachial Plexus Block Provides Safe and Comfortable Sedation : A Randomized Clinical Trialen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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