Tooth-Surface-Specific Effects of MI Varnish™ : A 3-Year Randomized Clinical Trial

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dc.contributor.authorGudkina, Jekaterīna
dc.contributor.authorAmaechi, Bennett T.
dc.contributor.authorAbrams, Stephen H.
dc.contributor.authorBrinkmane, Anda
dc.contributor.institutionDepartment of Conservative Dentistry and Oral Health
dc.date.accessioned2023-08-09T07:40:01Z
dc.date.available2023-08-09T07:40:01Z
dc.date.issued2023-08-07
dc.description.abstractAim: Our previous three-year randomized control trial showed that the application of MI Varnish™ (5% NaF/CPP-ACP) every 3 months reduced further caries development in 6- and 12-year-olds over a 3-year period. The purpose of this secondary analysis was to investigate whether MI Varnish™ had a differential effect on cumulative caries increment on different tooth surfaces. Methods: Group 1 (n = 48) (6-year-old children) and Group 3 (n = 47) (12-year-old children) received quarterly varnish applications, while Group 2 (n = 48) (6-year-old children) and Group 4 (n = 37) (12-year-old children) did not receive varnish applications. ICDAS caries scoring classified lesions as non-cavitated (n/c) lesions (ICDAS 1 and 2), cavitated (c) lesions (ICDAS II 3–6), non-cavitated lesions around restorations (CARn/c), and cavitated lesions around restorations (CARc). Thus, ‘decayed’ in DFS was calculated as (ICDAS 1–6 + CARn/c + CARc). The Chi-square test, Welch test (paired-t test), risk ratio test, and Pearson correlation coefficient were used for statistical analysis (α = 0.05). Results: After comparing baseline and 36-month data, in group 1, there was a significant (p < 0.01) reduction in caries in occlusal (23.11%) and proximal (21.35%) surfaces and a non-significant reduction in buccal/lingual surfaces (5.28%). In group 2, caries reduction was significant (p < 0.01) in occlusal surfaces (38.52%) but non-significant in proximal (7.78%) and buccal/lingual (7.12%) surfaces. In groups 3 and 4, significant (p < 0.001) increases in caries were observed in proximal (36.03% (group 3)/54.30% (group 4)) and buccal/lingual surfaces (51.02% (group 3)/45.98% (group 4)), and a non-significant increase was observed in occlusal surfaces (11.49% (group 3)/22.01% (group 4)). The relative risk had increased by 4% only on proximal surfaces in 6-year-olds. Conclusions: the application of MI Varnish™ every 3 months demonstrated a caries reduction effect on interproximal and occlusal surfaces among 6- and 12-year-old children. (Trial registration ISRCTN10584414).en
dc.description.statusPeer reviewed
dc.format.extent16
dc.format.extent978305
dc.identifier.citationGudkina, J, Amaechi, B T, Abrams, S H & Brinkmane, A 2023, 'Tooth-Surface-Specific Effects of MI Varnish™ : A 3-Year Randomized Clinical Trial', Oral, vol. 3, no. 3, pp. 372-388. https://doi.org/10.3390/oral3030030
dc.identifier.doi10.3390/oral3030030
dc.identifier.issn2673-6373
dc.identifier.otherMendeley: 41cc2fd9-c1e7-332c-bef8-b44e34dc04dd
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/14531
dc.identifier.urlhttps://www-webofscience-com.db.rsu.lv/wos/alldb/full-record/WOS:001269369200001
dc.language.isoeng
dc.relation.ispartofOral
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcaries increment
dc.subjectHygiene habits
dc.subjecttooth surface effect
dc.subjectMI Varnish™
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleTooth-Surface-Specific Effects of MI Varnish™ : A 3-Year Randomized Clinical Trialen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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