Placental histological inflammation and reproductive tract infections in a low risk pregnant population in Latvia

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dc.contributor.authorRezeberga, Dace
dc.contributor.authorLazdane, Gunta
dc.contributor.authorKroica, Juta
dc.contributor.authorSokolova, Ludmila
dc.contributor.authorDonders, Gilbert G.G.
dc.contributor.institutionDepartment of Obstetrics and Gynaecology
dc.contributor.institutionDepartment of Biology and Microbiology
dc.date.accessioned2021-10-29T08:25:01Z
dc.date.available2021-10-29T08:25:01Z
dc.date.issued2008
dc.description.abstractBackground. To investigate the correlation of reproductive tract infections (RTI) and endogenous vaginal flora at first antenatal consultation with placental histological inflammation. Methods. In a follow-up study, 154 low risk women with no miscarriage risk factors were examined for the presence of Neisseria gonorrhoeae, Trichomonas vaginalis, Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma hominis, Gardnerella vaginalis, Streptococcus agalactiae (GBS), Staphylococcus aureus, Enterococcus faecalis (GDS) and bacterial vaginosis (BV). At delivery, outcome data were collected and the histology of the placenta was studied. Results. Some 85 (56.3%) of all pregnant women had RTI or endogenous vaginal flora. Placental histological inflammation correlated with genital tract colonisation with G. vaginalis (p =0.013), BV (p =0.031), S. aureus (p =0.04) and aerobic vaginitis (p =0.017). BV and BV-related G. vaginalis correlated with the presence of parietal and placental chorioamnionitis in 53.8 and 43.5% of cases. Genital tract colonisation with GDS and other aerobic flora in combination with inflammatory vaginitis correlated with the presence of funisitis in 33.3 and 40.0% of cases. Mycoplasmas increased the risk for intrauterine infection only when present in combination with other RTIs (p =0.023). Conclusion. Histological placental inflammation is associated with both BV and genital tract colonisation with aerobic bacteria, while funisitis is associated with colonisation of aerobic bacteria at first prenatal visit before the 17th gestational week.en
dc.description.statusPeer reviewed
dc.format.extent6
dc.format.extent60714
dc.identifier.citationRezeberga, D, Lazdane, G, Kroica, J, Sokolova, L & Donders, G G G 2008, 'Placental histological inflammation and reproductive tract infections in a low risk pregnant population in Latvia', Acta Obstetricia et Gynecologica Scandinavica, vol. 87, no. 3, pp. 360-365. https://doi.org/10.1080/00016340801936487
dc.identifier.doi10.1080/00016340801936487
dc.identifier.issn0001-6349
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6753
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=39849085496&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofActa Obstetricia et Gynecologica Scandinavica
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAerobic vaginitis
dc.subjectBacterial vaginosis
dc.subjectChorioamnionitis
dc.subjectEndogenous vaginal flora
dc.subjectPlacenta
dc.subjectReproductive tract infections
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectObstetrics and Gynaecology
dc.titlePlacental histological inflammation and reproductive tract infections in a low risk pregnant population in Latviaen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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