In Vitro Safety and Efficacy Evaluation of a Juniperus communis Callus Culture Extract and Matricaria recutita Processing Waste Extract Combination as a Cosmetic Ingredient

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dc.contributor.authorRamata-Stunda, Anna
dc.contributor.authorBoroduskis, Martins
dc.contributor.authorPastare, Laura
dc.contributor.authorBerga, Marta
dc.contributor.authorKienkas, Liene
dc.contributor.authorPatetko, Liene
dc.contributor.authorSkudrins, Gundars
dc.contributor.authorReihmane, Dace
dc.contributor.authorNakurte, Ilva
dc.date.accessioned2024-01-29T15:20:01Z
dc.date.available2024-01-29T15:20:01Z
dc.date.issued2024-01-18
dc.descriptionPublisher Copyright: © 2024 by the authors.
dc.description.abstractFor skin health promotion and cosmetic applications, combinations of plant cell extracts are extensively utilized. As most natural ingredient suppliers offer crude extracts from individual plants or specific isolated compounds, the potential interactions between them are assessed in the development phase of cosmetic products. The industry seeks extract combinations that have undergone optimization and scrutiny for their bioactivities. This study presents a combination of two sustainably produced botanical ingredients and outlines their chemical composition, in vitro safety, and bioactivity for skin health enhancement. The amalgamation comprises the extract of Matricaria recutita processing waste and the extract from Juniperus communis callus culture. Chemical analysis revealed distinct compounds within the extracts, and their combination led to a broader array of potentially synergistic compounds. In vitro assessments on skin cells demonstrated that the combination possesses robust antioxidant properties and the ability to stimulate keratinocyte proliferation, along with regulating collagen type I and matrix metalloproteinase 1 (MMP-1) production by dermal fibroblasts. The identified traits of this combination render it an appealing cosmetic component. To the best of our knowledge, this represents the first case when the extracts derived from medicinal plant processing waste and biotechnological plant cell cultivation processes have been combined and evaluated for their bioactivity.en
dc.description.statusPeer reviewed
dc.format.extent16
dc.format.extent2224458
dc.identifier.citationRamata-Stunda, A, Boroduskis, M, Pastare, L, Berga, M, Kienkas, L, Patetko, L, Skudrins, G, Reihmane, D & Nakurte, I 2024, 'In Vitro Safety and Efficacy Evaluation of a Juniperus communis Callus Culture Extract and Matricaria recutita Processing Waste Extract Combination as a Cosmetic Ingredient', Plants, vol. 13, no. 2, 287. https://doi.org/10.3390/plants13020287
dc.identifier.doi10.3390/plants13020287
dc.identifier.issn2223-7747
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/15137
dc.identifier.urlhttps://www.webofscience.com/wos/alldb/full-record/MEDLINE:38256840
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85183108883&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofPlants
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGerman chamomile
dc.subjectvalorization
dc.subjectjuniper
dc.subjectplant callus culture
dc.subjectchemical composition
dc.subjectcytotoxicity
dc.subjectphototoxicity
dc.subjectcollagen production
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleIn Vitro Safety and Efficacy Evaluation of a Juniperus communis Callus Culture Extract and Matricaria recutita Processing Waste Extract Combination as a Cosmetic Ingredienten
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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