The postmedieval Latvian oral microbiome in the context of modern dental calculus and modern dental plaque microbial profiles

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dc.contributor.authorKazarina, Alisa
dc.contributor.authorPetersone‐Gordina, Elina
dc.contributor.authorKimsis, Janis
dc.contributor.authorKuzmicka, Jevgenija
dc.contributor.authorZayakin, Pawel
dc.contributor.authorGriškjans, Žans
dc.contributor.authorGerhards, Guntis
dc.contributor.authorRanka, Renate
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2022-01-27T12:05:01Z
dc.date.available2022-01-27T12:05:01Z
dc.date.issued2021-02
dc.descriptionFunding Information: Funding: This work was supported by ERDF grant number 1.1.1.1/16/A/101 (to R.R. and G.G.). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractRecent advantages in paleomicrobiology have provided an opportunity to investigate the composition of ancient microbial ecologies. Here, using metagenome analysis, we investigated the microbial profiles of historic dental calculus retrieved from archaeological human remains from postmedieval Latvia dated 16–17th century AD and examined the associations of oral taxa and microbial diversity with specific characteristics. We evaluated the preservation of human oral micro-biome patterns in historic samples and compared the microbial composition of historic dental cal-culus, modern human dental plaque, modern human dental calculus samples and burial soil micro-biota. Overall, the results showed that the majority of microbial DNA in historic dental calculus originated from the oral microbiome with little impact of the burial environment. Good preservation of ancient DNA in historical dental calculus samples has provided reliable insight into the composition of the oral microbiome of postmedieval Latvian individuals. The relative stability of the classifiable oral microbiome composition was observed. Significant differences between the micro-biome profiles of dental calculus and dental plaque samples were identified, suggesting microbial adaptation to a specific human body environment.en
dc.description.statusPeer reviewed
dc.format.extent15
dc.format.extent1648414
dc.identifier.citationKazarina, A, Petersone‐Gordina, E, Kimsis, J, Kuzmicka, J, Zayakin, P, Griškjans, Ž, Gerhards, G & Ranka, R 2021, 'The postmedieval Latvian oral microbiome in the context of modern dental calculus and modern dental plaque microbial profiles', Genes, vol. 12, no. 2, 309. https://doi.org/10.3390/genes12020309
dc.identifier.doi10.3390/genes12020309
dc.identifier.issn2073-4425
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/7333
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85102173450&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofGenes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAncient DNA
dc.subjectDental calculus
dc.subjectDental plaque
dc.subjectMetagenomics
dc.subjectOral microbiome
dc.subject1.6 Biological sciences
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGenetics
dc.subjectGenetics(clinical)
dc.titleThe postmedieval Latvian oral microbiome in the context of modern dental calculus and modern dental plaque microbial profilesen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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