Evidence of human parvovirus B19 infection in the post-mortem brain tissue of the elderly

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dc.contributor.authorSkuja, Sandra
dc.contributor.authorVilmane, Anda
dc.contributor.authorSvirskis, Simons
dc.contributor.authorGroma, Valerija
dc.contributor.authorMurovska, Modra
dc.contributor.institutionInstitute of Anatomy and Anthropology
dc.contributor.institutionInstitute of Microbiology and Virology
dc.date.accessioned2021-04-19T11:50:01Z
dc.date.available2021-04-19T11:50:01Z
dc.date.issued2018-11
dc.descriptionPublisher Copyright: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
dc.description.abstractAfter primary exposure, the human parvovirus B19 (B19V) genome may remain in the central nervous system (CNS), establishing a lifelong latency. The structural characteristics and functions of the infected cells are essential for the virus to complete its life cycle. Although B19V has been detected in the brain tissue by sequencing PCR products, little is known about its in vivo cell tropism and pathogenic potential in the CNS. To detect B19V and investigate the distribution of its target cells in the CNS, we studied brain autopsies of elderly subjects using molecular virology, and optical and electron microscopy methods. Our study detected B19V in brain tissue samples from both encephalopathy and control groups, suggesting virus persistence within the CNS throughout the host’s lifetime. It appears that within the CNS, the main target of B19V is oligodendrocytes. The greatest number of B19V-positive oligodendrocytes was found in the white matter of the frontal lobe. The number was significantly lower in the gray matter of the frontal lobe (p = 0.008) and the gray and white matter of the temporal lobes (p < 0.0001). The morphological changes observed in the encephalopathy group, propose a possible B19V involvement in the demyelination process.en
dc.description.statusPeer reviewed
dc.format.extent2926428
dc.identifier.citationSkuja, S, Vilmane, A, Svirskis, S, Groma, V & Murovska, M 2018, 'Evidence of human parvovirus B19 infection in the post-mortem brain tissue of the elderly', Viruses, vol. 10, no. 11, 582. https://doi.org/10.3390/v10110582
dc.identifier.doi10.3390/v10110582
dc.identifier.issn1999-4915
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3842
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85055637991&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofViruses
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectElderly
dc.subjectElectron microscopy
dc.subjectGlia
dc.subjectImmunohistochemistry
dc.subjectParvovirus B19
dc.subjectPCR
dc.subject3.1 Basic medicine
dc.subject3.3 Health sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectInfectious Diseases
dc.subjectVirology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleEvidence of human parvovirus B19 infection in the post-mortem brain tissue of the elderlyen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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