Flavonoids in the Spotlight : Bridging the Gap between Physicochemical Properties and Formulation Strategies

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dc.contributor.authorBerga, Marta
dc.contributor.authorLogviss, Konstantīns
dc.contributor.authorLauberte, Līga
dc.contributor.authorPaulausks, Artūrs
dc.contributor.authorMohylyuk, Valentyn
dc.contributor.institutionLaboratory of Finished Dosage Forms
dc.date.accessioned2023-10-05T13:15:01Z
dc.date.available2023-10-05T13:15:01Z
dc.date.issued2023-10-03
dc.descriptionPublisher Copyright: © 2023 by the authors.
dc.description.abstractFlavonoids are hydroxylated polyphenols that are widely distributed in plants with diverse health benefits. Despite their popularity, the bioavailability of flavonoids is often overlooked, impacting their efficacy and the comparison of products. The study discusses the bioavailability-related physicochemical properties of flavonoids, with a focus on the poorly soluble compounds commonly found in dietary supplements and herbal products. This review sums up the values of pKa, log P, solubility, permeability, and melting temperature of flavonoids. Experimental and calculated data were compiled for various flavonoid subclasses, revealing variations in their physicochemical properties. The investigation highlights the challenges posed by poorly soluble flavonoids and underscores the need for enabling formulation approaches to enhance their bioavailability and therapeutic potential. Compared to aglycones, flavonoid glycosides (with sugar moieties) tend to be more hydrophilic. Most of the reviewed aglycones and glycosides exhibit relatively low log P and high melting points, making them “brick dust” candidates. To improve solubility and absorption, strategies like size reduction, the potential use of solid dispersions and carriers, as well as lipid-based formulations have been discussed.en
dc.description.statusPeer reviewed
dc.format.extent4215341
dc.identifier.citationBerga, M, Logviss, K, Lauberte, L, Paulausks, A & Mohylyuk, V 2023, 'Flavonoids in the Spotlight : Bridging the Gap between Physicochemical Properties and Formulation Strategies', Pharmaceuticals, vol. 16, no. 10, 1407. https://doi.org/10.3390/ph16101407
dc.identifier.doi10.3390/ph16101407
dc.identifier.issn1424-8247
dc.identifier.otherMendeley: c20b9280-9eca-3127-bb78-ce7e0d75ca65
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/14910
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85175013478&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofPharmaceuticals
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectlog P
dc.subjectbrick dust
dc.subjectpermeability
dc.subjectsolubility
dc.subjectpK
dc.subjectsolubility parameters
dc.subjectflavonoids
dc.subjectdevelopability classification system
dc.subjectgrease balls
dc.subjectphysiochemical properties
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectDrug Discovery
dc.subjectMolecular Medicine
dc.subjectPharmaceutical Science
dc.titleFlavonoids in the Spotlight : Bridging the Gap between Physicochemical Properties and Formulation Strategiesen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

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