Moderate traumatic brain injury triggers long-term risks for the development of peripheral pain sensitivity and depressive-like behavior in mice

Simple item page
dc.contributor.authorStelfa, Gundega
dc.contributor.authorSvalbe, Baiba
dc.contributor.authorVavers, Edijs
dc.contributor.authorDuritis, Ilmars
dc.contributor.authorDambrova, Maija
dc.contributor.authorZvejniece, Liga
dc.contributor.institutionDepartment of Pharmaceutical Chemistry
dc.date.accessioned2022-10-27T11:15:01Z
dc.date.available2022-10-27T11:15:01Z
dc.date.issued2022-09-20
dc.descriptionFunding Information: This study was supported by the framework of EU-ERA-NET NEURON CnsAflame and TRAINS. Publisher Copyright: Copyright © 2022 Stelfa, Svalbe, Vavers, Duritis, Dambrova and Zvejniece.
dc.description.abstractAs traumatic brain injury (TBI) is one of the major causes of permanent disability, there is increasing interest in the long-term outcome of TBI. While motor deficits, cognitive impairment and longer-term risks of neurodegenerative disease are well-established consequences in animal models of TBI, pain is discussed less often despite its high prevalence. The current study addresses the need to characterize the extent of chronic pain and long-term behavioral impairments induced by moderate lateral fluid percussion injury (latFPI) in mice up to 12 months post-TBI and evaluates the validity of the model. Adult male BALB/c mice were subjected to latFPI, and the results were compared with outcomes in sham-operated mice. Mouse behavior was assessed at 1 and 7 days and 1, 3, 6, 9, and 12 months post-injury using sensory-motor (neurological severity score, NSS), cold (acetone) and mechanical sensitivity (von Frey), depressive-like behavior (tail suspension), locomotor (open field), motor coordination (rotarod) and cognitive (Morris water maze, y-maze, passive avoidance) tests. Animals with TBI demonstrated significantly higher NSS than the sham-operated group for up to 9 months after the injury. Cold sensitization was significantly increased in the contralateral hind paw in the TBI group compared to that of the sham group at 3, 6, and 9 months after TBI. In the von Frey test, the withdrawal threshold of the contralateral and ipsilateral hind paws was reduced at 6 months after TBI and lasted for up to 12 months post-injury. latFPI induced progressive depressive-like behavior starting at 6 months post-injury. No significant deficits were observed in memory, motor coordination or locomotion over the 12-month assessment period. The present study demonstrates that moderate TBI in mice elicits long-lasting impairment of sensory-motor function, results in progressive depression and potentiates peripheral pain. Hence, the latFPI model provides a relevant preclinical setting for the study of the link between brain injury and chronic sequelae such as depression and peripheral pain.en
dc.description.statusPeer reviewed
dc.format.extent1277938
dc.identifier.citationStelfa, G, Svalbe, B, Vavers, E, Duritis, I, Dambrova, M & Zvejniece, L 2022, 'Moderate traumatic brain injury triggers long-term risks for the development of peripheral pain sensitivity and depressive-like behavior in mice', Frontiers in Neurology, vol. 13, 985895. https://doi.org/10.3389/fneur.2022.985895
dc.identifier.doi10.3389/fneur.2022.985895
dc.identifier.issn1664-2295
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/9680
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85139188560&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofFrontiers in Neurology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectdepression
dc.subjectlateral fluid percussion injury
dc.subjectlong-term behavioral outcome
dc.subjectpain
dc.subjecttraumatic brain injury
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectNeurology
dc.subjectClinical Neurology
dc.titleModerate traumatic brain injury triggers long-term risks for the development of peripheral pain sensitivity and depressive-like behavior in miceen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Moderate_traumatic_brain_injury_triggers_long_term_risks.pdf
Size:
1.22 MB
Format:
Adobe Portable Document Format
Download

Collections

Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure