Gallbladder Interleukins in Children with Calculous Cholecystitis

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dc.contributor.authorDeņisova, Arina
dc.contributor.authorPilmane, Māra
dc.contributor.authorEņģelis, Arnis
dc.contributor.authorPētersons, Aigars
dc.contributor.institutionInstitute of Anatomy and Anthropology
dc.contributor.institutionDepartment of Paediatric Surgery
dc.date.accessioned2021-08-06T15:10:01Z
dc.date.available2021-08-06T15:10:01Z
dc.date.issued2021-09
dc.descriptionPublisher Copyright: Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).
dc.description.abstractCalculous cholecystitis connects to inflammation and various complications. It is a common disease in the paediatric population, yet it is still uncertain how inflammation factors are involved in its morphopathogenesis. Twenty calculous cholecystitis surgery tissue samples were obtained from 20 children. As a control, seven unaffected gallbladders were used. Tissues were immunohistochemically stained for IL-1α, IL-4, IL-6, IL-7, IL-8, IL-10, and IL-17A, and the slides were inspected by light microscopy. To evaluate statistical differences and correlations between interleukins, Mann–Whitney U and Spearman’s tests were used. Statistically significant difference between patient and control gallbladder epithelium was for IL-1α and IL-17A, but connective tissue—IL-1α, IL-4, IL-6, IL-7, IL-8, and IL-17A positive structures. A strong positive correlation in patients was detected between epithelial IL-1α and IL-1α in connective tissue, epithelial IL-6 and IL-7, IL-6 and IL-17A, IL-7 and IL-10, IL-7 and IL-17A, as well as between IL-6 and IL-7, IL-7 and IL-10 in connective tissue. The increase of IL-1α, IL-4, IL-6, IL-7, IL-8 and IL-17A positive structures suggests their role in the morphopathogenesis of calculous cholecystitis. The correlations between interleukins in epithelium and in connective tissues prove that the epithelial barrier function and inflammatory response in deeper layers are sustained through intercellular signalling pathways.en
dc.description.statusPeer reviewed
dc.format.extent13
dc.format.extent6961566
dc.identifier.citationDeņisova, A, Pilmane, M, Eņģelis, A & Pētersons, A 2021, 'Gallbladder Interleukins in Children with Calculous Cholecystitis', Pediatric Reports, vol. 13, no. 3, pp. 470-482. https://doi.org/10.3390/pediatric13030054
dc.identifier.doi10.3390/pediatric13030054
dc.identifier.issn2036-749X
dc.identifier.otherMendeley: 69f98188-f158-377f-b7e5-4006959d4b26
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/5967
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85113678962&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofPediatric Reports
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcholecystitis
dc.subjectgallbladder
dc.subjectchildren
dc.subjectinterleukins
dc.subjectepithelium
dc.subjectconnective tissue
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleGallbladder Interleukins in Children with Calculous Cholecystitisen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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