Role of serum cytokines in acute appendicitis and acute mesenteric lymphadenitis among children

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dc.contributor.authorZviedre, Astra
dc.contributor.authorEngelis, Arnis
dc.contributor.authorTretjakovs, Peteris
dc.contributor.authorJurka, Antra
dc.contributor.authorZile, Irisa
dc.contributor.authorPetersons, Aigars
dc.contributor.institutionDepartment of Paediatric Surgery
dc.contributor.institutionDepartment of Human Physiology and Biochemistry
dc.contributor.institutionDepartment of Public Health and Epidemiology
dc.date.accessioned2021-06-22T09:55:01Z
dc.date.available2021-06-22T09:55:01Z
dc.date.issued2016
dc.descriptionFunding Information: The study was financially supported by a Grant No. 2009/0147/1DP/1.1.2.1.2/09/IPIA/VIAA/009 from the project Support for Doctoral and Post-doctoral Investigations Riga Stradiņš University fellowship and a Grant No. 2010.10-4/VPP-4 of the framework of the Latvian National Program and also by The national Research program project Biomedicine for public health (BIOMEDICINE) No 6.1 “Research on acute and chronic diseases in a wide age-range children to develop diagnostic and therapeutic algorithms to reduce mortality, prolong survival and improve quality of life”. Publisher Copyright: © 2016 The Lithuanian University of Health Sciences
dc.description.abstractBackground and objective The diagnostic role of serum cytokines depends on the etiology and pathogenesis of acute appendicitis (AA) and acute mesenteric lymphadenitis (AML). The aim of this study was to evaluate differences in cytokine levels between AA and AML. Materials and methods Data of 7- to 18-year-old children were collected prospectively from October 2010 to October 2013. There were 31 patients with AA (AA group), 26 with AML (AML group), and 17 with elective non-inflammatory surgical disease (control group). Serum levels of IL-10, IL-12(p70), IL-1β, IL-4, IL-6, IL-8, IL-17, MCP-1, EGF, TNF-α and white blood count (WBC) were measured three times consecutively in each group. Results The level of IL-6 and IL-10 was significantly higher in the AA group than the AML group at the first measurement (8 pg/mL vs. 3.2 pg/mL, P = 0.000; 6.1 pg/mL vs. 3.2 pg/mL, P = 0.005, respectively). There was a significant difference observed in time dynamics of concentration of IL-6 and MCP-1 for AA and AML. The area under the curve (AUC) was 0.77 (95% CI 0.64–0.89; P = 0.001) for IL-6 with a cut-off value of 4.3 pg/mL (67.7% sensitivity and 76.9% specificity) for AA 1 h before surgery. The AUC for WBC was 0.72 (95% CI 0.58.4–0.85; P = 0.005) with a cut-off value of 10.7 × 103/μL (sensitivity 71.0% and specificity 46.2%). Conclusions Serum IL-6 with a cut-off value of 4.3 pg/mL and WBC with a cut-off value of 10.7 × 103/μL assessed together will yield more sensitivity for AA.en
dc.description.statusPeer reviewed
dc.format.extent7
dc.format.extent563467
dc.identifier.citationZviedre, A, Engelis, A, Tretjakovs, P, Jurka, A, Zile, I & Petersons, A 2016, 'Role of serum cytokines in acute appendicitis and acute mesenteric lymphadenitis among children', Medicina (Lithuania), vol. 52, no. 5, pp. 291-297. https://doi.org/10.1016/j.medici.2016.10.002
dc.identifier.doi10.1016/j.medici.2016.10.002
dc.identifier.issn1010-660X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/5413
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84993996047&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofMedicina (Lithuania)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAppendicitis
dc.subjectChildren
dc.subjectCytokines
dc.subjectMesenteric lymphadenitis
dc.subject3.2 Clinical medicine
dc.subject1.6 Biological sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.titleRole of serum cytokines in acute appendicitis and acute mesenteric lymphadenitis among childrenen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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