Appearance and distribution of tissue remodellation factors in the hard tissue of patients affected by cleft lip palate

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dc.contributor.authorBuile, Dace
dc.contributor.authorPilmane, Māra
dc.contributor.authorAkota, Ilze
dc.contributor.institutionInstitute of Anatomy and Anthropology
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2021-09-06T12:15:01Z
dc.date.available2021-09-06T12:15:01Z
dc.date.issued2020-06-01
dc.descriptionFunding Information: This study was funded by Riga Stradins University, No. 5-1/106/2019 from 12.04.2019, “The elaboration of diagnostic prognostic factor algorithm of facial tissue complex regeneration for cleft patients in longitudinal aspect”. Publisher Copyright: © 2020 Sciendo. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
dc.description.abstractBone repair after surgical intervention on cleft lip palate (CLP) depends on the coordinated action of multiple tissue regeneration factors. We determined the relative number and appearance of tissue factors: matrix metalloproteinase-2 (MMP-2), tissue inhibitor of metalloproteinase-2 (TIMP-2), bone morphogenetic protein 2/4 (BMP 2/4), transforming growth factor beta (TGF-ß), Wnt3a protein (Wnt3a), Runt-related transcription factor 2 (Runx2), basic fibroblast growth factor (bFGF) and osteoprotegerin in hard tissue of CLP patients during first time surgical intervention. Fourtythree CLP patients with 24 bone and 36 cartilage samples were involved. Immunohistochemistry was used to assess the levels of tissue factors and the semi-quantitative census method was used for quantification of immunological structures. The increased amount of MMP-2 and bFGF positive cells was detected in the CLP group in cartilage and bone (p < 0.05), compared to the controls. A statistically significant (p = 0.012) increased amount of BMP 2/4 positive cells was found in cartilage of CLP patients, in comparison to the control group. Increased appearance of MMP-2, bFGF in hard tissue of the CLP patients indicates the predominance of tissue degradation. Increased number of BMP2/4 positive chondrocytes suggests improved cartilage growth and better regeneration in CLP patients.en
dc.description.statusPeer reviewed
dc.format.extent10
dc.format.extent1494031
dc.identifier.citationBuile, D, Pilmane, M & Akota, I 2020, 'Appearance and distribution of tissue remodellation factors in the hard tissue of patients affected by cleft lip palate', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 74, no. 3, pp. 171-180. https://doi.org/10.2478/prolas-2020-0028
dc.identifier.doi10.2478/prolas-2020-0028
dc.identifier.issn1407-009X
dc.identifier.otherunpaywall: 10.2478/prolas-2020-0028
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6190
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85091199858&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGrowth factors
dc.subjectHuman
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAppearance and distribution of tissue remodellation factors in the hard tissue of patients affected by cleft lip palateen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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