Basic Fibroblast Growth Factor (bFGF), Fibroblast Growth Factor Receptor 1 (FGFR1), Transforming Growth Factor Beta (TGF-β) and Chromogranin A (CgA) Appearance in Congenital Intra-abdominal Adhesions in Children under One Year of Age

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dc.contributor.authorAugule, Anna
dc.contributor.authorPilmane, Māra
dc.contributor.authorĀbola, Zane
dc.contributor.authorVolrāts, Olafs
dc.contributor.institutionInstitute of Anatomy and Anthropology
dc.contributor.institutionDepartment of Paediatric Surgery
dc.date.accessioned2021-11-29T13:00:01Z
dc.date.available2021-11-29T13:00:01Z
dc.date.issued2015-09-09
dc.description.abstractAim: Of this work was to determine dispersion of TGF-b, fibrosis modulating factor (bFGF and FGR1) and granule marker chromogranin A in case of intra-abdominal adhesion which could be essential factors in disease pathogenesis. Thus than could be used as possible biomarker. Study Design: Observational study. Place of Study: Institute of Anatomy and Anthropology and Department of Children Surgery, Rīga Stradiņš University. Materials and Methods: The specimens used for research were obtained from 50 patients aged 1 to 292 days. They underwent abdominal surgery due to obstructive gut malrotation and several additional pathologies. Tissues were processed for bFGF, FGFR1, TGF-β and CgA by means of biotin-streptavidin immunohistochemistry. Results: In adhesion tissue bFGF positive connective tissue cells varied from a few to an abundant amount, but in 15 specimens no positive structure was observed. Few connective tissue fibers and moderate to numerous fibroblasts and macrophages contained FGFR1. A moderate number of TGF-β positive connective tissue fibers were observed. Some specimens also contained positive fibroblasts, macrophages and endotheliocytes. Few connective tissue cells contained CgA. A moderate correlation was observed between bFGF and FGFR1 (Spearman’s rank correlation coefficient = .500, P < .001) as well as between bFGF and CgA (Spearman’s rank correlation coefficient = .311, P = .03). Conclusions: The connection between the less distinct bFGF and more prominent FGFR1 proves the compensatory stimulation of receptors as a response on the lack of the same factor in case of adhesion disease. Persisting appearance of TGF-β positive structures in congenital adhesions indicates the continuing growth/regeneration potential of loose connective tissue. Positive CgA structures indicate the involvement of the neuroendocrine system in case of adhesion disease.en
dc.description.statusPeer reviewed
dc.format.extent312323
dc.identifier.citationAugule, A, Pilmane, M, Ābola, Z & Volrāts, O 2015, 'Basic Fibroblast Growth Factor (bFGF), Fibroblast Growth Factor Receptor 1 (FGFR1), Transforming Growth Factor Beta (TGF-β) and Chromogranin A (CgA) Appearance in Congenital Intra-abdominal Adhesions in Children under One Year of Age', British Journal of Medicine and Medical Research, vol. 10, no. 11, 19676, pp. 1-9. https://doi.org/10.9734/BJMMR/2015/19676
dc.identifier.doi10.9734/BJMMR/2015/19676
dc.identifier.issn2231-0614
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6912
dc.language.isoeng
dc.relation.ispartofBritish Journal of Medicine and Medical Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectchildren
dc.subjectadhesions
dc.subjectgrowth factors
dc.subjectimmunohistochemistry
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions)
dc.titleBasic Fibroblast Growth Factor (bFGF), Fibroblast Growth Factor Receptor 1 (FGFR1), Transforming Growth Factor Beta (TGF-β) and Chromogranin A (CgA) Appearance in Congenital Intra-abdominal Adhesions in Children under One Year of Ageen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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