Cumulative Small Effect Genetic Markers and the Risk of Colorectal Cancer in Poland, Estonia, Lithuania, and Latvia

Simple item page
dc.contributor.authorSerrano-Fernandez, Pablo
dc.contributor.authorDymerska, Dagmara
dc.contributor.authorKurzawski, Grzegorz
dc.contributor.authorDerkacz, Róza
dc.contributor.authorSobieszczańska, Tatiana
dc.contributor.authorBanaszkiewicz, Zbigniew
dc.contributor.authorRoomere, Hanno
dc.contributor.authorOitmaa, Eneli
dc.contributor.authorMetspalu, Andres
dc.contributor.authorJanavičius, Ramunas
dc.contributor.authorElsakov, Pavel
dc.contributor.authorRazumas, Mindaugas
dc.contributor.authorPetrulis, Kestutis
dc.contributor.authorIrmejs, Arvids
dc.contributor.authorMiklaševičs, Edvins
dc.contributor.authorScott, Rodney J.
dc.contributor.authorLubiński, Jan
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2021-07-02T11:45:01Z
dc.date.available2021-07-02T11:45:01Z
dc.date.issued2015
dc.descriptionPublisher Copyright: © 2015 Pablo Serrano-Fernandez et al.
dc.description.abstractThe continued identification of new low-penetrance genetic variants for colorectal cancer (CRC) raises the question of their potential cumulative effect among compound carriers. We focused on 6 SNPs (rs380284, rs4464148, rs4779584, rs4939827, rs6983267, and rs10795668), already described as risk markers, and tested their possible independent and combined contribution to CRC predisposition. Material and Methods. DNA was collected and genotyped from 2330 unselected consecutive CRC cases and controls from Estonia (166 cases and controls), Latvia (81 cases and controls), Lithuania (123 cases and controls), and Poland (795 cases and controls). Results. Beyond individual effects, the analysis revealed statistically significant linear cumulative effects for these 6 markers for all samples except of the Latvian one (corrected P value = 0.018 for the Estonian, corrected P value = 0.0034 for the Lithuanian, and corrected P value = 0.0076 for the Polish sample). Conclusions. The significant linear cumulative effects demonstrated here support the idea of using sets of low-risk markers for delimiting new groups with high-risk of CRC in clinical practice that are not carriers of the usual CRC high-risk markers.en
dc.description.statusPeer reviewed
dc.format.extent10
dc.format.extent702884
dc.identifier.citationSerrano-Fernandez, P, Dymerska, D, Kurzawski, G, Derkacz, R, Sobieszczańska, T, Banaszkiewicz, Z, Roomere, H, Oitmaa, E, Metspalu, A, Janavičius, R, Elsakov, P, Razumas, M, Petrulis, K, Irmejs, A, Miklaševičs, E, Scott, R J & Lubiński, J 2015, 'Cumulative Small Effect Genetic Markers and the Risk of Colorectal Cancer in Poland, Estonia, Lithuania, and Latvia', Gastroenterology Research and Practice, vol. 2015, 204089. https://doi.org/10.1155/2015/204089
dc.identifier.doi10.1155/2015/204089
dc.identifier.issn1687-6121
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/5822
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84935836599&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofGastroenterology Research and Practice
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMedicine
dc.subject3.2 Clinical medicine
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectHepatology
dc.subjectGastroenterology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleCumulative Small Effect Genetic Markers and the Risk of Colorectal Cancer in Poland, Estonia, Lithuania, and Latviaen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Cumulative_Small_Effect_Genetic_Markers.pdf
Size:
686.41 KB
Format:
Adobe Portable Document Format
Download

Collections

Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure