Immunohistochemical expression of HBME-1, E-cadherin, and CD56 in the differential diagnosis of thyroid nodules

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dc.contributor.authorOzolins, Arturs
dc.contributor.authorNarbuts, Zenons
dc.contributor.authorStrumfa, Ilze
dc.contributor.authorVolanska, Guna
dc.contributor.authorStepanovs, Kaspars
dc.contributor.authorGardovskis, Janis
dc.contributor.institutionDepartment of Surgery
dc.contributor.institutionDepartment of Pathology
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2021-06-09T07:05:01Z
dc.date.available2021-06-09T07:05:01Z
dc.date.issued2012
dc.descriptionCopyright: Copyright 2020 Elsevier B.V., All rights reserved.
dc.description.abstractBackground and Objective. Distinction between benign and malignant thyroid tumors is essential for proper clinical management. The aim of this study was to evaluate the diagnostic potential of a set of 3 molecular markers in the differential diagnosis of thyroid tumors. Material and Methods. Immunohistochemistry for HBME-1, E-cadherin (E-CAD), and CD56 was carried out in 36 follicular adenomas, 77 colloid goiters, 36 papillary thyroid carcinomas, and 14 follicular carcinomas. Sixty-eight thyroid fine needle aspiration(FNA) cases confirmed by subsequent surgical resection specimens were selected. Immunocytochemistry for HBME-1, E-CAD, and CD56 was performed in these cases, including 25 papillary thyroid carcinomas, 1 follicular carcinoma, 22 follicular adenomas, and 20 colloid goiters. Results. PTC was characterized by a decreased expression of E-CAD and CD56 contrary to the surrounding benign thyroid tissues. There was no HBME-1 expression in benignthyroid tissues, but it was high in papillary thyroid carcinomas and weak in follicular adenomas. The expression of E-CAD and CD56 was significantly higher in follicular adenomas than in the surrounding thyroid tissues. Analyzing the FNA material, HBME-1 expression was documented in 96% of papillary thyroid carcinomas, but there was no expression in the benign lesions. E-CAD and CD56 expression was significantly weakened in papillary thyroid carcinomas, but enhanced in follicular adenomas. Conclusions. HBME-1 was found only in malignant lesions and can be considered the most sensitive, specific single marker in papillary thyroid carcinomas. CD56 and E-CAD can assist in the decision-making on thebenign and malignant nature of the nodule. Immunocytochemistry is of value as an ancillary test to enhance the diagnostic accuracy of thyroid FNA samples.en
dc.description.statusPeer reviewed
dc.format.extent8
dc.format.extent1355416
dc.identifier.citationOzolins, A, Narbuts, Z, Strumfa, I, Volanska, G, Stepanovs, K & Gardovskis, J 2012, 'Immunohistochemical expression of HBME-1, E-cadherin, and CD56 in the differential diagnosis of thyroid nodules', Medicina (Lithuania), vol. 48, no. 10, pp. 507-514. https://doi.org/10.3390/medicina48100074
dc.identifier.doi10.3390/medicina48100074
dc.identifier.issn1010-660X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/4808
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84875543577&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofMedicina (Lithuania)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCD56
dc.subjectE-cadherin
dc.subjectHBME-1
dc.subjectImmunohistochemistry
dc.subjectThyroid nodules
dc.subject3.2 Clinical medicine
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.titleImmunohistochemical expression of HBME-1, E-cadherin, and CD56 in the differential diagnosis of thyroid nodulesen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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