Performance of contrast-enhanced ultrasound in thyroid nodules : Review of current state and future perspectives

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dc.contributor.authorRadzina, Maija
dc.contributor.authorRatniece, Madara
dc.contributor.authorPutrins, Davis Simanis
dc.contributor.authorSaule, Laura
dc.contributor.authorCantisani, Vito
dc.contributor.institutionDepartment of Radiology
dc.date.accessioned2021-11-22T12:10:05Z
dc.date.available2021-11-22T12:10:05Z
dc.date.issued2021-10-30
dc.descriptionPublisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractUltrasound has been established as a baseline imaging technique for thyroid nodules. The main advantage of adding CEUS is the ability to assess the sequence and intensity of vascular perfusion and hemodynamics in the thyroid nodule, thus providing real-time characterization of nodule features, considered a valuable new approach in the determination of benign vs. malignant nod-ules. Original studies, reviews and six meta-analyses were included in this article. A total of 624 studies were retrieved, and 107 were included in the study. As recognized for thyroid nodule malignancy risk stratification by US, for acceptable accuracy in malignancy a combination of several CEUS parameters should be applied: hypo-enhancement, heterogeneous, peripheral irregular enhancement in combination with internal enhancement patterns, and slow wash-in and wash-out curve lower than in normal thyroid tissue. In contrast, homogeneous, intense enhancement with smooth rim enhancement and “fast-in and slow-out” are indicative of the benignity of the thyroid nodule. Even though overlapping features require standardization, with further research, CEUS may achieve reliable performance in detecting or excluding thyroid cancer. It can also play an op-erative role in guiding ablation procedures of benign and malignant thyroid nodules and metastatic lymph nodes, and providing accurate follow-up imaging to assess treatment efficacy.en
dc.description.statusPeer reviewed
dc.format.extent19
dc.format.extent31394057
dc.identifier.citationRadzina, M, Ratniece, M, Putrins, D S, Saule, L & Cantisani, V 2021, 'Performance of contrast-enhanced ultrasound in thyroid nodules : Review of current state and future perspectives', Cancers, vol. 13, no. 21, 5469. https://doi.org/10.3390/cancers13215469
dc.identifier.doi10.3390/cancers13215469
dc.identifier.issn2072-6694
dc.identifier.otherunpaywall: 10.3390/cancers13215469
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6856
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85118109633&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofCancers
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectContrast-enhanced ultrasound (CEUS)
dc.subjectFollicular thyroid cancer
dc.subjectPapillary thyroid cancer
dc.subjectThyroid cancer
dc.subjectThyroid nodules
dc.subject3.2 Clinical medicine
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectOncology
dc.subjectCancer Research
dc.subjectSDG 3 - Good Health and Well-being
dc.titlePerformance of contrast-enhanced ultrasound in thyroid nodules : Review of current state and future perspectivesen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

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