Oxidative stress parameters in Posttraumatic Stress Disorder risk group patients

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dc.contributor.authorVoicehovskis, Vladimirs
dc.contributor.authorAncane, Gunta
dc.contributor.authorVoicehovska, Julija
dc.contributor.authorOrlikovs, Grigorijs
dc.contributor.authorKarpovs, Jurijs
dc.contributor.authorIvanovs, Igors
dc.contributor.authorŠkesters, Andrejs
dc.contributor.authorAncans, Andrejs
dc.contributor.authorSilova, Alise
dc.contributor.authorIvaščenko, Tarass
dc.contributor.authorMicans, Janis
dc.contributor.authorVaivads, Normunds
dc.contributor.authorUmnova, Larisa
dc.contributor.institutionDepartment of Psychosomatic Medicine and Psychotherapy
dc.contributor.institutionDepartment of Internal Diseases
dc.contributor.institutionBioķīmijas zinātniskā laboratorija
dc.contributor.institutionDepartment of Pathology
dc.date.accessioned2021-05-25T08:25:02Z
dc.date.available2021-05-25T08:25:02Z
dc.date.issued2012
dc.descriptionFunding Information: The research is supported by European Social Foundation co-financing: Project for Doctoral students support, at Rîga Stradiòð University (No. 2009/0147/1DP/1.1.2.1.2/09/IPIA/ VIAA/009). The views expressed in this article are those of the authors and do not reflect the official policy or position of the Latvian government, Latvian National Armed Forces, Medical Support Centre of Latvian National Armed Forces or any of the institutions with which the authors are affiliated. The authors state no conflict of interest. All authors read and approved the final manuscript.
dc.description.abstractIncreased excitotoxity in response to stressors leads to oxidative stress (OS) due to accumulation of excess reactive oxygen/nitrogen species. Neuronal membrane phospholipids are especially susceptible to oxidative damage, which alters signal transduction mechanisms. The Contingent of International Operations (CIO) has been subjected to various extreme stressors that could cause Posttraumatic Stress Disorder (PTSD). Former studies suggest that heterogeneity due to gender, race, age, nutritional condition and variable deployment factors and stressors produce challenges in studying these processes. The research aim was to assess OS levels in the PTSD risk group in CIO. In a prospective study, 143 participants who were Latvian CIO, regular personnel, males, Europeans, average age of 27.4, with the same tasks during the mission, were examined two months before and immediately after a six-month Peace Support Mission (PSM) in Afghanistan. PCL-M questionnaire, valid Latvian language "Military" version was used for PTSD evaluation. Glutathione peroxidase (GPx), superoxide dismutase (SOD) and lipid peroxidation intensity and malondialdehyde (MDA) as OS indicators in blood were determined. Data were processed using SPSS 20.0. The MDA baseline was 2.5582 μM, which after PSM increased by 24.36% (3.1815 μM). The GPx baseline was 8061.98 U/L, which after PSM decreased by 9.35% (7308.31 U/L). The SOD baseline was 1449.20 U/gHB, which after PSM increased by 2.89% (1491.03 U/gHB). The PTSD symptom severity (total PCL-M score) baseline was 22.90 points, which after PSM increased by 14.45% (26.21 points). The PTSD Prevalence rate (PR) baseline was 0.0357, which after PSM increased by 147.06% (0.0882). We conclude that there is positive correlation between increase of OS, PTSD symptoms severity level, and PTSD PR in a group of patients with risk of PTSD - CIO. PTSD PR depends on MDA intensity and OS severity. OS and increased free radical level beyond excitotoxity, is a possible causal factor for clinical manifestation of PTSD.en
dc.description.statusPeer reviewed
dc.format.extent9
dc.format.extent193069
dc.identifier.citationVoicehovskis, V, Ancane, G, Voicehovska, J, Orlikovs, G, Karpovs, J, Ivanovs, I, Škesters, A, Ancans, A, Silova, A, Ivaščenko, T, Micans, J, Vaivads, N & Umnova, L 2012, 'Oxidative stress parameters in Posttraumatic Stress Disorder risk group patients', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 66, no. 6, pp. 242-250. https://doi.org/10.2478/v10046-012-0016-x
dc.identifier.doi10.2478/v10046-012-0016-x
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/4522
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84886921016&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOxidative stress
dc.subjectPosttraumatic stress disorder
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.titleOxidative stress parameters in Posttraumatic Stress Disorder risk group patientsen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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