Selenium Status and Oxidative Stress in SARS-CoV-2 Patients

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dc.contributor.authorŠķesters, Andrejs
dc.contributor.authorLece, Anna
dc.contributor.authorKustovs, Dmitrijs
dc.contributor.authorZolovs, Maksims
dc.contributor.institutionBioķīmijas zinātniskā laboratorija
dc.contributor.institutionDepartment of Pharmaceutical Chemistry
dc.contributor.institutionStatistics Unit
dc.date.accessioned2023-04-25T18:30:01Z
dc.date.available2023-04-25T18:30:01Z
dc.date.issued2023-03
dc.descriptionFunding Information: The present study was part of the Research Programme of LATVIA “Clinical, biochemical, immunogenetic paradigms of COVID-19 infection and their correlation with socio-demographic, etiological, pathogenetic, diagnostic, therapeutically and prognostically important factors to be included in guidelines” (VPP-COVID-2020/1-002). Publisher Copyright: © 2023 by the authors.
dc.description.abstractBackground and Objectives: Insufficient intake of essential micronutrient selenium (Se) increases the susceptibility to diseases associated with oxidative stress. The study aim was to assess Se status and oxidative stress in COVID-19 patients depending on severity of the disease. Materials and Methods: Blood plasma of 80 post-COVID-19 disease patients and 40 acutely ill patients were investigated. Concentration of Se was detected by a fluorometric method with di-amino-naphthalene using acidic hydrolysis. Selenoprotein P (Sepp1), malondialdehyde (MDA), and 4-hydroxynonenal (4-HNE) and their metabolite adducts were evaluated by spectrophotometric methods using commercial assay kits. Results: Obtained results demonstrated that Se and Sepp1 concentration in acute patients were significantly (p < 0.05 for Se and p < 0.001 for Sepp1) decreased compared with post-COVID-19 disease patients. However, in post-COVID-19 disease patients, Se values were close to the low limit of the norm for the European population. 4-HNE adducts concentration as a marker of lipid peroxidation was significantly increased in the acute patients group compared to the recovery group (p < 0.001). Conclusions: COVID-19 pathology is characterized by the induction of oxidative stress and suppression of antioxidant defenses during the acute phase. Lower levels of Se and Sepp1 and higher levels of reactive oxygen species reflect this imbalance, highlighting the role of oxidative stress in the disease’s pathogenesis.en
dc.description.statusPeer reviewed
dc.format.extent10
dc.format.extent695597
dc.identifier.citationŠķesters, A, Lece, A, Kustovs, D & Zolovs, M 2023, 'Selenium Status and Oxidative Stress in SARS-CoV-2 Patients', Medicina (Lithuania), vol. 59, no. 3, 527, pp. 1-10. https://doi.org/10.3390/medicina59030527, https://doi.org/10.3390/medicina59030527
dc.identifier.doi10.3390/medicina59030527
dc.identifier.issn1010-660X
dc.identifier.otherPubMedCentral: PMC10052009
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/11784
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85152297434&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofMedicina (Lithuania)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject4-HNE adducts
dc.subjectCOVID-19
dc.subjectoxidative stress
dc.subjectreactive oxygen species
dc.subjectselenium, selenoprotein P
dc.subject3.1 Basic medicine
dc.subject1.4 Chemical sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.titleSelenium Status and Oxidative Stress in SARS-CoV-2 Patientsen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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