Laboratory Tests in Addition to the Alvarado Score in the Management of Acute Appendicitis in School-Age Children

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dc.contributor.authorZviedre, Astra
dc.contributor.authorEņgelis, Arnis
dc.contributor.authorTretjakovs, Peteris
dc.contributor.authorZile, Irisa
dc.contributor.authorPetersons, Aigars
dc.contributor.institutionDepartment of Paediatric Surgery
dc.contributor.institutionDepartment of Human Physiology and Biochemistry
dc.contributor.institutionDepartment of Public Health and Epidemiology
dc.date.accessioned2021-04-20T13:25:03Z
dc.date.available2021-04-20T13:25:03Z
dc.date.issued2019-08-01
dc.descriptionFunding Information: The study was financially supported by a Grant No. 2010.10-4/VPP-4 of the framework of the Latvian National Programme and Grant No. 2009/0147/1DP/1.1.2.1.2/09/ IPIA/VIAA/009 from the project Support for Doctoral and Post-doctoral Investigations Rîga Stradiòð University fellowship. Publisher Copyright: © 2019 Astra Zviedre et al., published by Sciendo 2019.
dc.description.abstractThe aim of the study was to determine whether the Alvarado score (AS) together with laboratory tests could be used to distinguish patients with acute appendicitis (AA) from acute mesenteric lymphadenitis (AML). Fifty-seven patients (7-18 years) with suspected AA were included in the prospective study (October 2010 - October 2013). Thirty-one patients underwent surgery for AA and 26 were not treated surgically and were diagnosed AML on ultrasonography. AS, white blood cell count (WBC), C - reactive protein (CRP) and serum cytokines (EGF, IL-10, IL-12(p70), IL-1β, IL-4, IL-6, IL-8, IL-17, MCP-1, TNF-α) were obtained on admission and were compared between groups. Mean age of the 57 patients was 12.9 (SD 3.2). Accuracy (AR) for AS ≥ 7 alone was 73.7% for AA. Modified AS with certain serum cytokines seemed to be a reliable tool for initial differential diagnosis between AA and AML in school-age children. Based on these results, AS ≥ 7, WBC ≥ 10.7 × 103/μL and serum IL-6 ≥ 4.3 pg/mL assessed altogether will yield more sensitivity for AA. Also for further advanced diagnostics, we propose to take into account the serum IL-6, IL-8, MCP-1, CRP cut-off levels in the differential diagnosis between complicated and uncomplicated AA to decide whether the treatment should be conservative or surgical.en
dc.description.statusPeer reviewed
dc.format.extent8
dc.format.extent553028
dc.identifier.citationZviedre, A, Eņgelis, A, Tretjakovs, P, Zile, I & Petersons, A 2019, 'Laboratory Tests in Addition to the Alvarado Score in the Management of Acute Appendicitis in School-Age Children', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 73, no. 4, pp. 379-386. https://doi.org/10.2478/prolas-2019-0059
dc.identifier.doi10.2478/prolas-2019-0059
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3872
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85069684925&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlvarado score
dc.subjectappendicitis
dc.subjectmesenteric lymphadenitis
dc.subjectserum cytokines
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.titleLaboratory Tests in Addition to the Alvarado Score in the Management of Acute Appendicitis in School-Age Childrenen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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