Presence of B19V in Patients with Thyroid Gland Disorders

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dc.contributor.authorGravelsina, Sabine
dc.contributor.authorNora-Krukle, Zaiga
dc.contributor.authorSvirskis, Simons
dc.contributor.authorCunskis, Egils
dc.contributor.authorMurovska, Modra
dc.date.accessioned2021-01-13T12:28:32Z
dc.date.available2021-01-13T12:28:32Z
dc.date.issued2019
dc.description.abstractBackground and Objectives: Viral infections are frequently cited as a major environmental factor implicated in thyroid gland diseases. This work aimed to estimate the presence of B19V infection in patients with thyroid gland disorders. Materials and Methods: Thyroid gland tissue and blood samples of 50 patients with autoimmune thyroid gland diseases (AITDs), 76 patients with non-autoimmune thyroid gland diseases (non-AITDs), and 35 deceased subjects whose histories did not show any autoimmune or thyroid diseases (control group) were enrolled in the study. Virus-specific IgM and IgG were detected using ELISA, and the presence and viral load of B19V in the tissue and blood were detected using PCRs. Results: B19V IgG antibodies were detected in 35/50 AITDs patients and in 51/76 non-AITDs patients, and B19V IgM antibodies were detected in 1/50 patients with AITDs and in none of the 76 patients with non-AITDs. The B19V NS sequence was found in the tissue DNA of 10/50 patients with AITDs, in 30/76 with non-AITDs, and in 1/35 control group individuals. The median B19V load in the tissue of patients with AITDs and non-AITDs was 423.00 copies/µg DNA (IQR: 22.50–756.8) and 43.00 copies/µg DNA (IQR: 11.50–826.5), respectively. The viral load in one of the 35 nPCR B19V-positive thyroid tissue samples from the deceased subjects was 13.82 copies/µg DNA. The viral load in the tissue of patients with AITDs was higher than in whole blood, which possibly indicates B19V persistency in thyrocytes (p = 0.0076). Conclusion: The fact that the genoprevalence of B19V NS was significantly higher in patients with non-AITDs compared to the control group and in the thyroid gland tissue of patients with AITDs, and that the non-AITDs viral load was higher than in tissue derived from the control group individuals, suggest the possibility that B19V infection could be involved in the development of thyroid gland diseases.en_US
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/2893
dc.language.isoenen_US
dc.relation.ispartofMedicina 2019, 55(12), 774; https://doi.org/10.3390/medicina55120774en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectB19Ven_US
dc.subjectthyroid gland diseasesen_US
dc.titlePresence of B19V in Patients with Thyroid Gland Disordersen_US
dc.typeArticleen_US

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