A novel one-pot synthesis and characterization of silk fibroin/α-calcium sulfate hemihydrate for bone regeneration

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dc.contributor.authorPandey, Aditi
dc.contributor.authorYang, Tzu Sen
dc.contributor.authorCheng, Shu Lien
dc.contributor.authorHuang, Ching Shuan
dc.contributor.authorBrangule, Agnese
dc.contributor.authorKareiva, Aivaras
dc.contributor.authorYang, Jen Chang
dc.contributor.institutionDepartment of Pharmaceutical Chemistry
dc.date.accessioned2021-07-06T08:55:02Z
dc.date.available2021-07-06T08:55:02Z
dc.date.issued2021-06-18
dc.descriptionFunding Information: Funding: Support for this work was provided by the Ministry of Science and Technology, Taiwan MOST 109-2224-E-038-002. The APC was funded by MOST. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractThis study aims to fabricate silk fibroin/calcium sulfate (SF/CS) composites by one-pot synthesis for bone regeneration applications. The SF was harvested from degummed silkworm cocoons, dissolved in a solvent system comprising of calcium chloride:ethanol:water (1:2:8), and then mixed with a stoichiometric amount of sodium sulfate to prepare various SF/CS composites. The crystal pattern, glass transition temperature, and chemical composition of SF/CS samples were analyzed by XRD, DSC, and FTIR, respectively. These characterizations revealed the successful synthesis of pure calcium sulfate dihydrate (CSD) and calcium sulfate hemihydrate (CSH) when it was combined with SF. The thermal analysis through DSC indicated molecular-level interaction between the SF and CS. The FTIR deconvolution spectra demonstrated an increment in the β-sheet content by increasing CS content in the composites. The investigation into the morphology of the composites using SEM revealed the formation of plate-like dihydrate in the pure CS sample, while rod-like structures of α-CSH surrounded by SF in the composites were observed. The compressive strength of the hydrated 10 and 20% SF-incorporated CSH composites portrayed more than a twofold enhancement (statistically significant) in comparison to that of the pure CS samples. Reduced compressive strength was observed upon further increasing the SF content, possibly due to SF agglomeration that restricted its uniform distribution. Therefore, the one-pot synthesized SF/CS composites demonstrated suitable chemical, thermal, and morphological properties. However, additional biological analysis of its potential use as bone substitutes is required.en
dc.description.statusPeer reviewed
dc.format.extent20293714
dc.identifier.citationPandey, A, Yang, T S, Cheng, S L, Huang, C S, Brangule, A, Kareiva, A & Yang, J C 2021, 'A novel one-pot synthesis and characterization of silk fibroin/α-calcium sulfate hemihydrate for bone regeneration', Polymers, vol. 13, no. 12, 1996. https://doi.org/10.3390/polym13121996
dc.identifier.doi10.3390/polym13121996
dc.identifier.issn2073-4360
dc.identifier.otherunpaywall: 10.3390/polym13121996
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/5834
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85108712768&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofPolymers
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCalcium sulfate hemihydrate
dc.subjectSilk fibroin
dc.subject1.4 Chemical sciences
dc.subject3.1 Basic medicine
dc.subject3.4 Medical biotechnology
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Chemistry
dc.subjectPolymers and Plastics
dc.titleA novel one-pot synthesis and characterization of silk fibroin/α-calcium sulfate hemihydrate for bone regenerationen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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