Circulating irisin in healthy adults : Changes after acute exercise, correlation with body composition, and energy expenditure parameters in cross-sectional study

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dc.contributor.authorLagzdina, Rudite
dc.contributor.authorRumaka, Maija
dc.contributor.authorGersone, Gita
dc.contributor.authorTretjakovs, Peteris
dc.contributor.institutionDepartment of Human Physiology and Biochemistry
dc.date.accessioned2021-09-08T06:25:01Z
dc.date.available2021-09-08T06:25:01Z
dc.date.issued2020-06
dc.descriptionPublisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
dc.description.abstractBackground and Objectives: Skeletal muscles are considered to be the main source of circulating irisin, both at rest and during physical activity. The aim of this study was to investigate the connection between irisin, body composition, and energy metabolism in humans. Materials and Methods: Serum irisin concentrations before and after acute aerobic exercise on a treadmill in 84 healthy adults were measured and their association with body composition and energy expenditure (EE) (obtained from indirect calorimetry) was determined. Results: The total pre-exercise irisin concentrations in males and females were similar, but higher in females when expressed per body mass kg (p <0.001). There was an association between pre-exercise irisin per body mass kg, visceral fat rating (rho = −0.52, p = 0.001), and lean tissue % (rho = 0.41, p <0.05) in males and lean body mass index (LBMI) (rho = −0.59, p <0.001) in females. The pre-exercise irisin concentration correlated with the resting metabolic rate (RMR) in both sexes (rho = 0.44 in males, rho = 0.36 in females; p <0.05), but with walking, running, and the EE difference from RMR in running (∆ running EE) in males only (rho = 0.32 to 0.37, p <0.05). There was no significant change in irisin concentration after exercise in 58% of participants, while it decreased in 23%, and increased in 19%. In male subjects with no change in irisin concentration after exercise, running (p < 0.05) and ∆ running EE per body mass kg (p <0.05) were higher than in those with decreased irisin concentration. Conclusions: These findings indicate that the association of irisin concentration with body composition and EE parameters has sex-dependent differences, and acute exercise can lead to various changes in post-exercise irisin levels.en
dc.description.statusPeer reviewed
dc.format.extent11
dc.format.extent1110805
dc.identifier.citationLagzdina, R, Rumaka, M, Gersone, G & Tretjakovs, P 2020, 'Circulating irisin in healthy adults : Changes after acute exercise, correlation with body composition, and energy expenditure parameters in cross-sectional study', Medicina (Lithuania), vol. 56, no. 6, 274, pp. 1-11. https://doi.org/10.3390/medicina56060274
dc.identifier.doi10.3390/medicina56060274
dc.identifier.issn1010-660X
dc.identifier.otherunpaywall: 10.3390/medicina56060274
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6239
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85086280938&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofMedicina (Lithuania)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBody composition
dc.subjectEnergy expenditure
dc.subjectHealthy adults
dc.subjectIrisin
dc.subjectPhysical exercise
dc.subjectResting metabolic rate
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.titleCirculating irisin in healthy adults : Changes after acute exercise, correlation with body composition, and energy expenditure parameters in cross-sectional studyen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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