Histopathologic and immunohistochemical lesions in liver of mink infected with Aleutian disease virus
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Date
2011
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Abstract
Parvovirus of Aleutian disease causes mainly damage to kidneys, but immune complexes deposition and damage may occur also in other organs. In mink farms of Latvia the liver dystrophy or hepatic lipidosis of mink is widely distributed. The goal of this study was to examine probability of liver damage and regeneration of mink infected with Aleutian disease virus. Liver injury was assessed histologically. The mink liver demonstrated inflammation of liver parenchyma and foci of fatty liver. In immunohistochemistry, during liver regeneration the matrix metalloproteinases MMP-9, vascular endothelial growth factor and ß-defensin 2 expressions were lower, but MMP-2 and nerve growth factor receptor p75 expression was increased.
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Keywords
Aleutian disease, Immunohistochemistry, Liver, Mink, 3.1 Basic medicine, 4.3 Veterinary science, 1.1. Scientific article indexed in Web of Science and/or Scopus database, General Veterinary
Citation
Valdovska, A & Pilmane, M 2011, 'Histopathologic and immunohistochemical lesions in liver of mink infected with Aleutian disease virus', Polish Journal of Veterinary Sciences, vol. 14, no. 1, pp. 69-76. https://doi.org/10.2478/v10181-011-0010-2