Recombinant Human Nerve Growth Factor (Cenegermin)–Driven Corneal Wound Healing Process : An Evidence-Based Analysis

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dc.contributor.authorBonzano, Chiara
dc.contributor.authorOlivari, Sara
dc.contributor.authorCutolo, Carlo Alberto
dc.contributor.authorMacrì, Angelo
dc.contributor.authorSindaco, Daniele
dc.contributor.authorBorroni, Davide
dc.contributor.authorBonzano, Elisabetta
dc.contributor.authorTraverso, Carlo Enrico
dc.date.accessioned2025-01-02T11:40:01Z
dc.date.available2025-01-02T11:40:01Z
dc.date.issued2022-01-28
dc.descriptionPublisher Copyright: Copyright © 2022 Bonzano, Olivari, Cutolo, Macrì, Sindaco, Borroni,.Bonzano and Traverso.
dc.description.abstractPurpose: To evaluate anterior segment optical coherence tomography (AS-OCT) to detect the wound healing process as per monitoring the effectiveness of cenegermin to treat moderate to severe neurotrophic keratoplasty. Methods: A retrospective chart review was realized to identify patients treated with cenegermin at the Clinica Oculistica, University of Genoa, Italy. All patients underwent careful examinations at baseline and follow-up visits. AS-OCT scans centered on the minimum corneal thickness (CT) area were always performed. We compared findings of AS-OCT with the findings from the slit-lamp examination. A linear regression analysis was used to evaluate factors associated with corneal healing. A further analysis, including a control group treated with 50% autologous serum (AS), was done to investigate and compare the efficacy of cenegermin. Results: Data from 16 eyes were studied. The average patients' age was 60.9 ± 21.1 years; five (31.2%) eyes experienced persistent epithelial defect and 11 (68.8%) eyes had neurotrophic corneal ulcer. The average reepithelialization time was 3.9 ± 0.5 weeks in the cenegermin group versus 5.9 ± 1.9 weeks in the AS group (p < 0.01). The AS‐OCT scans revealed an average CT at the thinnest point of 276.3 ± 74.1 μm before treatment with an average increase of 176.5 ± 60.3 μm at the end of the cenegermin treatment (B = −0.15; p = 0.035). The AS-OCT percentage increase in corneal thickness between the two groups was statistically significant (p < 0.02). Conclusion: Understanding the cascade of events involved in the nerve growth factor–driven corneal wound healing process is clinically meaningful for the clinician. AS-OCT is an effective tool for systematic anterior segment imaging, allowing the detailed detection of the front-to-back layered corneal structure for quantitative analysis and monitoring of the healing process.en
dc.description.statusPeer reviewed
dc.format.extent2162067
dc.identifier.citationBonzano, C, Olivari, S, Cutolo, C A, Macrì, A, Sindaco, D, Borroni, D, Bonzano, E & Traverso, C E 2022, 'Recombinant Human Nerve Growth Factor (Cenegermin)–Driven Corneal Wound Healing Process : An Evidence-Based Analysis', Frontiers in Pharmacology, vol. 12, 760507. https://doi.org/10.3389/fphar.2021.760507
dc.identifier.doi10.3389/fphar.2021.760507
dc.identifier.issn1663-9812
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/17000
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85124616430&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofFrontiers in Pharmacology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectanterior segment optical coherence tomography (AS-OCT)
dc.subjectautologous serum
dc.subjectcenegermin
dc.subjectcorneal diseases
dc.subjectneurotrophic keratoplasty
dc.subjectocular pharmacology
dc.subjectpharmacological targets
dc.subjectrh-NGF
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectPharmacology
dc.subjectPharmacology (medical)
dc.titleRecombinant Human Nerve Growth Factor (Cenegermin)–Driven Corneal Wound Healing Process : An Evidence-Based Analysisen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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