Impact of Depression on Cognitive Function and Disease Severity in Idiopathic Cervical Dystonia Patients : One-Center Data in Cross-Sectional Study

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dc.contributor.authorMeļņikova, Vlada
dc.contributor.authorValante, Ramona
dc.contributor.authorValtiņa-Briģe, Solveiga
dc.contributor.authorLogina, Ināra
dc.contributor.institutionDepartment of Neurology and Neurosurgery
dc.contributor.institutionDepartment of Doctoral Studies
dc.contributor.institutionDepartment of Anaesthesiology, Intensive Care and Clinical simulations
dc.date.accessioned2022-12-27T08:25:01Z
dc.date.available2022-12-27T08:25:01Z
dc.date.issued2022-12-05
dc.descriptionFunding Information: The APC was funded by Latvian Society of Neurologists (Reg. Nr. 40008017147; 13 Pilsonu Str, Riga, LV 1002, Latvia; Ph.: (+371) 67069420; Email: neirologubiedriba@gmail.com). Publisher Copyright: © 2022 by the authors.
dc.description.abstractBackground: Cervical dystonia is a highly disabling hyperkinetic movement disorder with a lot of nonmotor symptoms. One symptom with a high prevalence is depression, which may negatively affect dystonia patients. The aim of the study was to investigate the impact of depression on disease severity and cognitive functions in cervical dystonia patients. Methods: Patients with cervical dystonia were interviewed and divided into two groups, based on the Patient Health Questionnaire-9: those with no depression or mild depressive features and those with moderate, moderately severe, and severe depression. The severity of dystonia and cognitive functions were assessed and compared in both groups. Results: A total of 52 patients were investigated. Self-assessment of the disease was more negative in clinically significant depressive signs group ( p = 0.004), with a tendency for patients with clinically significant depressive features to have a slightly higher score on objective dystonia scales (TSUI and TWSTRS), but without statistically significant differences ( p = 0.387 and p = 0.244, respectively). Although not statistically significant, a slightly higher MoCA scale score was registered in cervical dystonia patients with clinically insignificant depressive signs. There was a tendency for worse results in the abstraction category in patients with clinically significant depression ( p = 0.056). Conclusions: Patients with clinically significant depression have a more negative self-assessment of the disease and perform worse in abstraction tasks.en
dc.description.statusPeer reviewed
dc.format.extent9
dc.format.extent809048
dc.identifier.citationMeļņikova, V, Valante, R, Valtiņa-Briģe, S & Logina, I 2022, 'Impact of Depression on Cognitive Function and Disease Severity in Idiopathic Cervical Dystonia Patients : One-Center Data in Cross-Sectional Study', Medicina (Kaunas, Lithuania), vol. 58, no. 12, 1793, pp. 1-9. https://doi.org/10.3390/medicina58121793, https://doi.org/10.3390/medicina58121793
dc.identifier.doi10.3390/medicina58121793
dc.identifier.issn1010-660X
dc.identifier.otherPubMedCentral: PMC9781028
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/9955
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85144524689&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofMedicina (Kaunas, Lithuania)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHumans
dc.subjectTorticollis/complications
dc.subjectCross-Sectional Studies
dc.subjectPatient Acuity
dc.subjectSeverity of Illness Index
dc.subjectCognition
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleImpact of Depression on Cognitive Function and Disease Severity in Idiopathic Cervical Dystonia Patients : One-Center Data in Cross-Sectional Studyen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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