The Impact of IL1B rs1143634 and DEFB1 rs11362 Variants on Periodontitis Risk in Phenylketonuria and Type 1 Diabetes Mellitus Patients in a Latvian Population

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dc.contributor.authorEmulina, Darta Elizabete
dc.contributor.authorĀbola, Iveta
dc.contributor.authorBrinkmane, Anda
dc.contributor.authorIsakovs, Aleksejs
dc.contributor.authorSkadiņš, Ingus
dc.contributor.authorMoisejevs, Georgijs
dc.contributor.authorGailīte, Linda
dc.contributor.authorAuzenbaha, Madara
dc.contributor.institutionScientific Laboratory of Molecular Genetics
dc.contributor.institutionDepartment of Conservative Dentistry and Oral Health
dc.contributor.institutionDepartment of Biology and Microbiology
dc.date.accessioned2024-02-05T08:55:02Z
dc.date.available2024-02-05T08:55:02Z
dc.date.issued2024
dc.descriptionPublisher Copyright: © 2024 by the authors.
dc.description.abstractObjectives: Periodontitis is a multifactorial disease that affects approximately 11% of the global population. The objective of this study was to examine whether, among individuals with phenylketonuria and type 1 diabetes mellitus, those with the IL1B rs1143634 and/or DEFB1 rs11362 genetic variants exhibit a higher periodontitis risk compared to healthy controls. Materials and Methods: In all, 43 phenylketonuria patients (aged 12–53), 28 type 1 diabetes mellitus patients (aged 11–40), and 63 healthy controls (aged 12–53) were included. The evaluation of periodontitis risk was conducted using the Silness–Löe plaque index, the Greene–Vermillion index, and an assessment for the necessity of calculus removal. Genetic variants rs1143634 and rs11362 were genotyped from salivary samples using restriction length polymorphism analysis. Results: The DEFB1 rs11362 variant was associated with higher Silness–Löe and Greene–Vermillion index scores in phenylketonuria patients (p = 0.011 and p = 0.043, respectively). The IL1B rs1143634 variant was associated with lower calculus removal necessity in type 1 diabetes mellitus patients (p = 0.030). Clinical examination showed the worst oral hygiene index scores for PKU patients. PKU patients also reported the least consistent tooth brushing and flossing habits. Conclusions: Genetic associations between DEFB1 rs11362 and IL1B rs1143634 variants and oral hygiene indices were observed in the PKU and T1DM groups, suggesting that genetic factors may contribute to periodontal health differences in these populations. Further research with a larger sample size is needed to confirm these findings and develop targeted oral health interventions.en
dc.description.statusPeer reviewed
dc.format.extent1097389
dc.identifier.citationEmulina, D E, Ābola, I, Brinkmane, A, Isakovs, A, Skadiņš, I, Moisejevs, G, Gailīte, L & Auzenbaha, M 2024, 'The Impact of IL1B rs1143634 and DEFB1 rs11362 Variants on Periodontitis Risk in Phenylketonuria and Type 1 Diabetes Mellitus Patients in a Latvian Population', Diagnosis, vol. 14, no. 2, 192. https://doi.org/10.3390/diagnostics14020192
dc.identifier.doi10.3390/diagnostics14020192
dc.identifier.issn2194-8011
dc.identifier.otherMendeley: 4aab7ac1-352c-30e5-981b-4d6ec7a189ea
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/15151
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85183174021&partnerID=8YFLogxK
dc.identifier.urlhttps://www.mendeley.com/catalogue/4aab7ac1-352c-30e5-981b-4d6ec7a189ea/
dc.language.isoeng
dc.relation.ispartofDiagnosis
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectoral hygiene indices
dc.subjectperiodontitis risk
dc.subjectPhenylketonuria
dc.subjectsingle nucleotide variants
dc.subjecttype 1 diabetes mellitus
dc.subjectphenylketonuria
dc.subject3.2 Clinical medicine
dc.subject1.6 Biological sciences
dc.subject3.1 Basic medicine
dc.subject3.3 Health sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectClinical Biochemistry
dc.subjectSDG 3 - Good Health and Well-being
dc.titleThe Impact of IL1B rs1143634 and DEFB1 rs11362 Variants on Periodontitis Risk in Phenylketonuria and Type 1 Diabetes Mellitus Patients in a Latvian Populationen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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