Central Nervous System Tuberculosis – Epidemiology, Pathogenesis, Clinical Course, Diagnosis and Treatment Outcomes
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Date
2022
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Rīgas Stradiņa universitāte
Rīga Stradiņš University
Rīga Stradiņš University
Abstract
Tuberkuloze joprojām ir liela veselības problēma visā pasaulē. Slimības ietekme ir asimetriska – vissmagāk skar attīstības valstis. Centrālās nervu sistēmas tuberkuloze ir vispostošākā slimības forma, kurai ir daudz komplikāciju un klīnisku izpausmju, kas smagi ietekmē skartos pacientus. Dažreiz sekas var būt mūža invaliditāte vai pat nāve. Vairāku zāļu rezistentie celmi apdraud veselības aprūpes sistēmas visā pasaulē, globālie ceļojumi palielina zāļu rezistences izplatības ātrumu, tādējādi ierobežojot iespējamās ārstēšanas iespējas. Tomēr nanotehnoloģijas un vispārējā izpratne par centrālās nervu sistēmas tuberkulozi var ietekmēt agrāku diagnostiku un precīzāku un efektīvāku ārstēšanu un tādējādi būt izšķiroši soļi mirstības samazināšanā. Šī literatūras apskata mērķis ir ieskicēt klīniskās izpausmes, efektīvu diagnostikas līdzekļu un terapijas izmantošanu, lai samazinātu CNS-TB ietekmi, tostarp potenciālo slazdu un šķēršļu analīzi, lai skartajiem pacientiem nodrošinātu vislabāko iespējamo iznākumu. Izmantotās datu bāzes bija PubMed, BMJ, Cochrane, ClinicalKey, Wiley un ESBCO, kopā 34 raksti, kas izturēja iekļaušanas kritērijus. Raksti tika analizēti pēc to sakarības, aktualitātes un statistiskā nozīmīguma.
Tuberculosis remains as a major health problem globally. The impact of the disease is asymmetric - the developing countries are the hardest hit. The tuberculosis of the central nervous system is the most devastating form of the disease, having plethora of complications and clinical manifestations leading to severe impact on affected patients. Sometimes the consequence can be life long disability or even death. The multi drug resistant strains pose a threat toward health care systems around the world, global travel increasing the speed of spread of drug resistance hence limiting possible treatment options. However, the nanotechnologies and general awareness of tuberculosis of the central nervous system may have impact in earlier diagnosis and more accurate and efficient treatment and thus be crucial steps in order to reduce mortality. The aim of this literature review is to outline the clinical manifestations, efficient use of diagnostic tools and therapy in order to reduce the impact of CNS-TB, including analysis of potential pitfalls and hindrances in order to deliver patients affected the best possible outcome. Databases used were PubMed, BMJ, Cochrane, ClinicalKey, Wiley and ESBCO, altogether 34 articles passing the inclusion criteria. The articles were analysed according to their relevancy, topicality and statistical significance.
Tuberculosis remains as a major health problem globally. The impact of the disease is asymmetric - the developing countries are the hardest hit. The tuberculosis of the central nervous system is the most devastating form of the disease, having plethora of complications and clinical manifestations leading to severe impact on affected patients. Sometimes the consequence can be life long disability or even death. The multi drug resistant strains pose a threat toward health care systems around the world, global travel increasing the speed of spread of drug resistance hence limiting possible treatment options. However, the nanotechnologies and general awareness of tuberculosis of the central nervous system may have impact in earlier diagnosis and more accurate and efficient treatment and thus be crucial steps in order to reduce mortality. The aim of this literature review is to outline the clinical manifestations, efficient use of diagnostic tools and therapy in order to reduce the impact of CNS-TB, including analysis of potential pitfalls and hindrances in order to deliver patients affected the best possible outcome. Databases used were PubMed, BMJ, Cochrane, ClinicalKey, Wiley and ESBCO, altogether 34 articles passing the inclusion criteria. The articles were analysed according to their relevancy, topicality and statistical significance.
Description
Medicīna
Medicine
Veselības aprūpe
Health Care
Medicine
Veselības aprūpe
Health Care
Keywords
Neirotuberkuloze, Centrālā nervu sistēmas tuberkuloze, Neurotuberculosis, central nervous system tuberculosis