Comparison of outcome between blood culture positive and negative infective endocarditis patients undergoing cardiac surgery

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dc.contributor.authorMeidrops, Kristians
dc.contributor.authorZuravlova, Arina
dc.contributor.authorOsipovs, Janis Davis
dc.contributor.authorKalejs, Martins
dc.contributor.authorGroma, Valerija
dc.contributor.authorPetrosina, Eva
dc.contributor.authorReinis, Aigars
dc.contributor.authorStrike, Eva
dc.contributor.authorDumpis, Uga
dc.contributor.authorErglis, Andrejs
dc.contributor.authorStradins, Peteris
dc.contributor.institutionRīga Stradiņš University
dc.contributor.institutionStatistics Unit
dc.contributor.institutionDepartment of Biology and Microbiology
dc.date.accessioned2021-06-30T10:40:01Z
dc.date.available2021-06-30T10:40:01Z
dc.date.issued2021-05-27
dc.descriptionPublisher Copyright: © 2021, The Author(s).
dc.description.abstractBackground: Up to 30% or even more of all infective endocarditis (IE) cases are recognized as blood culture negative, meaning that the causative agent is left unidentified. The prompt diagnosis together with the identification of causative microorganism and targeted antibiotic treatment can significantly impact the prognosis of the disease and further patient’s health status. In some studies, blood culture negative endocarditis has been shown to be associated with delayed diagnosis, worse outcome and course of the disease, and a greater number of intra and postoperative complications. Methods: We retrospectively analysed the medical records of all patients who underwent cardiac surgery for endocarditis between years 2016 and 2019. The aim of this study was to analyse short and long-term mortality and differences of laboratory, clinical and echocardiography parameters in patients with blood culture positive endocarditis (BCPE) and blood culture negative endocarditis (BCNE) and its possible impact on the clinical outcome. Results: In our study population were 114 (55.1%) blood culture positive and 93 (44.9%) blood culture negative cases of infectious endocarditis. The most common pathogens in the blood culture positive IE group were S.aureus in 36 cases (31.6%), Streptococcus spp. in 27 (23.7%), E.faecalis in 24 (21.1%), and other microorganisms in 27 (23.7%). Embolic events were seen in 60 patients (28.9%). In univariate analyses, detection of microorganism, elevated levels of procalcitonin were found to be significantly associated with intrahospital death, however it did not reach statistical significance in multivariate analyses. Among microorganisms, S.aureus was significantly associated with intrahospital death in both univariate and multivariate analyses. Conclusions: There are no statistically significant differences between groups of BCPE and BCNE in terms of intrahospital mortality, hospital and ICU stay or 3-year mortality. There were higher levels of procalcitonin in BCPE group, however procalcitonin failed to show independent association with mortality in multivariate analysis. The most common microorganism in the BCPE group was S.aureus. It was associated with independently higher intrahospital mortality when compared to other causative microorganisms.en
dc.description.statusPeer reviewed
dc.format.extent7
dc.format.extent671558
dc.identifier.citationMeidrops, K, Zuravlova, A, Osipovs, J D, Kalejs, M, Groma, V, Petrosina, E, Reinis, A, Strike, E, Dumpis, U, Erglis, A & Stradins, P 2021, 'Comparison of outcome between blood culture positive and negative infective endocarditis patients undergoing cardiac surgery', Journal of Cardiothoracic Surgery, vol. 16, no. 1, 147. https://doi.org/10.1186/s13019-021-01532-9
dc.identifier.doi10.1186/s13019-021-01532-9
dc.identifier.issn1749-8090
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/5746
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85107208041&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofJournal of Cardiothoracic Surgery
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBlood culture negative
dc.subjectBlood culture positive
dc.subjectInfective endocarditis
dc.subjectIntrahospital mortality
dc.subjectLong-term mortality
dc.subjectProcalcitonin
dc.subject3.2 Clinical medicine
dc.subject3.3 Health sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectSurgery
dc.subjectPulmonary and Respiratory Medicine
dc.subjectCardiology and Cardiovascular Medicine
dc.titleComparison of outcome between blood culture positive and negative infective endocarditis patients undergoing cardiac surgeryen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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