Quantitative Evaluation of Microcirculatory Alterations in Patients with COVID-19 and Bacterial Septic Shock through Remote Photoplethysmography and Automated Capillary Refill Time Analysis

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dc.contributor.authorKlibus, Māra
dc.contributor.authorSmirnova, Darja
dc.contributor.authorMarcinkevics, Zbignevs
dc.contributor.authorRubins, Uldis
dc.contributor.authorGrabovskis, Andris
dc.contributor.authorVanags, Indulis
dc.contributor.authorSabeļņikovs, Oļegs
dc.contributor.institutionDepartment of Clinical Skills and Medical Technologies
dc.contributor.institutionDepartment of Anaesthesiology, Intensive Care and Clinical simulations
dc.date.accessioned2024-10-15T09:30:01Z
dc.date.available2024-10-15T09:30:01Z
dc.date.issued2024-10-14
dc.description.abstractBackground and Objectives: Sepsis, a leading global health challenge, accounts for around 20% of deaths worldwide. The complexity of sepsis, especially the difference between bacterial and viral etiologies, requires an effective assessment of microcirculation during resuscitation. This study aimed to evaluate the impact of infusion therapy on microcirculation in patients with sepsis, focusing on bacterial- and COVID-19-associated sepsis using remote photoplethysmography (rPPG) and the automated capillary refill time (aCRT). Materials and Methods: This single-center prospective study was conducted in the ICU of Pauls Stradins Clinical University Hospital, including 20 patients with sepsis/septic shock. The patients were selected based on hemodynamic instability and divided into COVID-19 and Bacterial Septic Shock groups. Fluid responsiveness was assessed using the Passive Leg Raising Test (PLRT). Systemic hemodynamics and microcirculation were monitored through MAP CRT, rPPG, and serum lactate levels. Statistical analyses compared responses within and between the groups across different stages of the protocol. Results: The Bacterial group exhibited higher initial serum lactate levels and more pronounced microcirculatory dysfunction than the COVID-19 group. rPPG was more sensitive in detecting perfusion changes, showing significant differences between the groups. The automated CRT demonstrated greater sensitivity compared to the manual CRT, revealing significant differences during PLRT stages between bacterial- and COVID-19-associated sepsis. Both groups had a transient hemodynamic response to PLRT, with subsequent stabilization upon fluid infusion. Conclusions: When managing patients with sepsis in intensive care, monitoring microcirculation is of paramount importance in infusion therapy. Our study highlights the potential of rPPG and aCRT as tools for this purpose. These techniques can be used in conjunction with routine parameters, such as lactate levels and systemic hemodynamic parameters, to provide a comprehensive assessment of a patient’s condition.en
dc.description.statusPeer reviewed
dc.format.extent13
dc.format.extent1105532
dc.identifier.citationKlibus, M, Smirnova, D, Marcinkevics, Z, Rubins, U, Grabovskis, A, Vanags, I & Sabeļņikovs, O 2024, 'Quantitative Evaluation of Microcirculatory Alterations in Patients with COVID-19 and Bacterial Septic Shock through Remote Photoplethysmography and Automated Capillary Refill Time Analysis', Medicina, vol. 60, no. 10, 1680. https://doi.org/10.3390/medicina60101680
dc.identifier.doi10.3390/medicina60101680
dc.identifier.issn1648-9144
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/16750
dc.identifier.urlhttps://pubmed.ncbi.nlm.nih.gov/39459467/
dc.identifier.urlhttps://www-webofscience-com.db.rsu.lv/wos/alldb/full-record/MEDLINE:39459467
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85207688194&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofMedicina
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectseptic shock
dc.subjectremote photoplethysmography
dc.subjectautomated capillary refill time
dc.subjectmicrocirculation
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.titleQuantitative Evaluation of Microcirculatory Alterations in Patients with COVID-19 and Bacterial Septic Shock through Remote Photoplethysmography and Automated Capillary Refill Time Analysisen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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