Gut Microbiome Differences Regarding Lifestyle and the History of COVID-19 Disease in Ulcerative Colitis Patients

Simple item page
dc.contributor.authorStraume, Zane
dc.contributor.authorKrūmiņa, Nikola
dc.contributor.authorElbere, Ilze
dc.contributor.authorRozenberga, Maija
dc.contributor.authorBlomniece, Laura
dc.contributor.authorErts, Renārs
dc.contributor.authorRudzīte, Dace
dc.contributor.authorKloviņš, Jānis
dc.contributor.authorKrūmiņa, Angelika
dc.contributor.institutionDepartment of Internal Diseases
dc.contributor.institutionDepartment of Infectology
dc.date.accessioned2025-02-22T13:20:01Z
dc.date.available2025-02-22T13:20:01Z
dc.date.issued2024-08
dc.descriptionPublisher Copyright: © The Authors.
dc.description.abstractThe microbiome's role in ulcerative colitis pathogenesis is established. The influence of lifestyle on gut microbiome composition remains unclear, and interplay with COVID-19 disease warrants investigation. In a cross-sectional study conducted from June to December 2021, 49 outpatients from Rîga East Clinical University Hospital were included. Patients were categorised based on COVID-19 disease status (positive vs. negative) within the preceding six months. Lifestyle factors (smoking, alcohol consumption, physical activity, stress levels, and dietary patterns) were assessed and evaluated. Taxonomic classification of gut microbiome metagenome data was performed using MetaPhlAn v.2.6.0, with subsequent analysis conducted using SPSS 20.0. Thirty-one (63%) were male, and 18 (37%) were female patients. Fourteen patients (28.6%) tested positive for COVID-19. Gut microbiome composition differences were not observed between COVID-19 disease groups. Twenty-four (49%) patients engaged in sports activities and 30 (61.2%) patients reported a history of smoking. No significant microbiome differences were observed in groups regarding physical activity or smoking. Thirty-five (71.4%) were alcohol users, for whom Firmicutes abundance was significantly higher compared to non-users, p = 0.041. Patients reporting lower stress levels (18, 36.7%) exhibited higher Actinobacteria abundance compared to those with higher stress levels (31, 63.3%), p = 0.03. COVID-19 disease status did not affect gut microbiome composition, alcohol consumption and stress levels demonstrated significant associations.en
dc.description.statusPeer reviewed
dc.format.extent9
dc.format.extent255107
dc.identifier.citationStraume, Z, Krūmiņa, N, Elbere, I, Rozenberga, M, Blomniece, L, Erts, R, Rudzīte, D, Kloviņš, J & Krūmiņa, A 2024, 'Gut Microbiome Differences Regarding Lifestyle and the History of COVID-19 Disease in Ulcerative Colitis Patients', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 78, no. 4, pp. 266-274. https://doi.org/10.2478/prolas-2024-0037
dc.identifier.doi10.2478/prolas-2024-0037
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/17115
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85204065406&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectalcohol
dc.subjectdiet
dc.subjectlifestyle factors
dc.subjectsmoking
dc.subjectstress
dc.subject3.3 Health sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.titleGut Microbiome Differences Regarding Lifestyle and the History of COVID-19 Disease in Ulcerative Colitis Patientsen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Gut-Microbiome-Differences-Regarding-Lifestyle-and-the-History-of-COVID19-Disease-in-Ulcerative-Colitis-Patients.pdf
Size:
249.13 KB
Format:
Adobe Portable Document Format
Download

Collections

Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure