Features associated with melanoma metastasis in Latvia

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dc.contributor.authorPjanova, Dace
dc.contributor.authorRuklisa, Dace
dc.contributor.authorKregere, Elza
dc.contributor.authorAzarjana, Kristine
dc.contributor.authorOzola, Aija
dc.contributor.authorCema, Ingrida
dc.contributor.institutionMutes medicīnas katedra
dc.date.accessioned2021-09-10T08:50:01Z
dc.date.available2021-09-10T08:50:01Z
dc.date.issued2020-10
dc.descriptionFunding Information: This work was supported by The European Regional Development Fund (project no. 1.1.1.1/18/A/099). Publisher Copyright: © This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
dc.description.abstractCutaneous melanoma (CM) is the most aggressive form of skin cancer, exhibits an increasing incidence worldwide and has a high potential to develop metastasis. The current study aimed to identify a set of parameters that may aid in predicting the probability and timing of the onset of CM metastasis. A retrospective analysis was performed using the archive data of 2,026 patients with CM that were treated at the Riga East University Hospital Latvian Oncology Centre, which is the largest oncological hospital in the country, between 1998 and 2015. A case-control study design was employed, where patients with metastasis (n=278) were used as the cases and patients without metastasis were used as the controls. The present study examined the associations between metastasis and potential risk factors and constructed multivariate models of features that predicted metastasis using stepwise regression. Time until metastasis was analyzed using negative binomial regression models. The results of the present study indicated an increase in the number of melanomas that developed metastases during 1998-2015. Tumor Breslow thickness was demonstrated to be significantly larger in patients with metastasis compared with those without (P=0.012). The presence of ulceration significantly increased the risk of metastases [odds ratio (OR), 1.66; 95% CI, 1.07-2.59; P=0.033]. The absence of pigment in melanoma tissues was indicated to lead to a greater likelihood of metastasis (OR, 2.14; 95% CI, 1.10-4.19; P=0.035). Shorter times from diagnosis until the onset of metastases were observed in older patients (incident rate ratio (IRR), 6.85; 95% CI, 2.43-19.30; P=2.78×10 -4), and a borderline significant association was observed in those with ulcerated tumors (IRR, 1.33; 95% CI, 0.98-1.80; P=0.064). Therefore, the main features associated with the development of melanoma metastasis in Latvia were indicated to be tumor ulceration, absence of pigment and Breslow thickness.en
dc.description.statusPeer reviewed
dc.format.extent1568217
dc.identifier.citationPjanova, D, Ruklisa, D, Kregere, E, Azarjana, K, Ozola, A & Cema, I 2020, 'Features associated with melanoma metastasis in Latvia', Oncology Letters, vol. 20, no. 4, 11978. https://doi.org/10.3892/ol.2020.11978
dc.identifier.doi10.3892/ol.2020.11978
dc.identifier.issn1792-1074
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6301
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85089892410&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofOncology Letters
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBreslow thickness
dc.subjectMelanoma
dc.subjectMetastasis
dc.subjectPigment
dc.subjectPrognosis
dc.subjectSurvival
dc.subjectUlceration
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectOncology
dc.subjectCancer Research
dc.subjectSDG 3 - Good Health and Well-being
dc.titleFeatures associated with melanoma metastasis in Latviaen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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